Technology Process of (2S)-2-(2-18fluoroethyloxybenzyl)-4-(cis-3a,4,5,6,7,7a-hexahydroisoindolin-2-yl)-4-oxobutanoic acid
There total 8 articles about (2S)-2-(2-18fluoroethyloxybenzyl)-4-(cis-3a,4,5,6,7,7a-hexahydroisoindolin-2-yl)-4-oxobutanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: [2.2.2]cryptande; [18F]-potassium fluoride; potassium carbonate / acetonitrile / 0.17 h / 140 °C
2: sodium hydroxide; water / 1,4-dioxane / 1 h / 20 °C
With
[18F]-potassium fluoride; water; potassium carbonate; [2.2.2]cryptande; sodium hydroxide;
In
1,4-dioxane; acetonitrile;
DOI:10.1016/j.bmc.2014.04.059
- Guidance literature:
-
Multi-step reaction with 9 steps
1: potassium hydroxide / dimethyl sulfoxide / 15 h / 80 °C
2: sodium hydroxide; water / dimethyl sulfoxide / 5 h / 120 °C
3: acetic anhydride / dichloromethane / 1.5 h / 60 °C
4: dichloromethane / 5 h / 0 - 20 °C
5: thionyl chloride / 15.5 h / 0 - 20 °C
6: palladium 10% on activated carbon; hydrogen / methanol / 760.05 Torr
7: caesium carbonate / N,N-dimethyl-formamide / 40 °C
8: [2.2.2]cryptande; [18F]-potassium fluoride; potassium carbonate / acetonitrile / 0.17 h / 140 °C
9: sodium hydroxide; water / 1,4-dioxane / 1 h / 20 °C
With
thionyl chloride; [18F]-potassium fluoride; palladium 10% on activated carbon; water; hydrogen; acetic anhydride; potassium carbonate; caesium carbonate; [2.2.2]cryptande; potassium hydroxide; sodium hydroxide;
In
1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2014.04.059
- Guidance literature:
-
Multi-step reaction with 7 steps
1: acetic anhydride / dichloromethane / 1.5 h / 60 °C
2: dichloromethane / 5 h / 0 - 20 °C
3: thionyl chloride / 15.5 h / 0 - 20 °C
4: palladium 10% on activated carbon; hydrogen / methanol / 760.05 Torr
5: caesium carbonate / N,N-dimethyl-formamide / 40 °C
6: [2.2.2]cryptande; [18F]-potassium fluoride; potassium carbonate / acetonitrile / 0.17 h / 140 °C
7: sodium hydroxide; water / 1,4-dioxane / 1 h / 20 °C
With
thionyl chloride; [18F]-potassium fluoride; palladium 10% on activated carbon; water; hydrogen; acetic anhydride; potassium carbonate; caesium carbonate; [2.2.2]cryptande; sodium hydroxide;
In
1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2014.04.059
