C₁₈H₂₁NO₂

Base Information

• Chemical Name: C₁₈H₂₁NO₂
• CAS No.: 1608890-00-1
• Molecular Formula: C₁₈H₂₁NO₂
• Molecular Weight: 283.37
• Mol file: 1608890-00-1.mol

Synonyms:

Chemical Property of C₁₈H₂₁NO₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₂₁NO₂

There total 4 articles about C₁₈H₂₁NO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Benzaldoxime (932-90-1) → (3R,4S)-2-benzyl-4-hydroxymethyl-4-methyl-3-phenylisoxazolidine + C18H21NO2 (1608890-00-1)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium cyanoborohydride; hydrogenchloride / water; methanol / 4 h / 20 °C / pH Ca_. 2 / Inert atmosphere

2: sodium sulfate / dichloromethane / 18 h / Inert atmosphere

3: hydrogenchloride / water; nitromethane / 120 h / -20 °C / Inert atmosphere; Green chemistry

4: sodium tetrahydroborate / methanol

With hydrogenchloride; sodium tetrahydroborate; sodium cyanoborohydride; sodium sulfate; In methanol; nitromethane; dichloromethane; water;

DOI:10.1002/adsc.201300624

Reference yield:

N-benzyl hydroxylalmine (622-30-0) → (3R,4S)-2-benzyl-4-hydroxymethyl-4-methyl-3-phenylisoxazolidine + C18H21NO2 (1608890-00-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium sulfate / dichloromethane / 18 h / Inert atmosphere

2: hydrogenchloride / water; nitromethane / 120 h / -20 °C / Inert atmosphere; Green chemistry

3: sodium tetrahydroborate / methanol

With hydrogenchloride; sodium tetrahydroborate; sodium sulfate; In methanol; nitromethane; dichloromethane; water;

DOI:10.1002/adsc.201300624

Reference yield:

benzaldehyde (100-52-7) → (3R,4S)-2-benzyl-4-hydroxymethyl-4-methyl-3-phenylisoxazolidine + C18H21NO2 (1608890-00-1)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium hydroxide; hydroxylamine hydrochloride / ethanol / 0.25 h / 20 °C / Inert atmosphere

2: sodium cyanoborohydride; hydrogenchloride / water; methanol / 4 h / 20 °C / pH Ca_. 2 / Inert atmosphere

3: sodium sulfate / dichloromethane / 18 h / Inert atmosphere

4: hydrogenchloride / water; nitromethane / 120 h / -20 °C / Inert atmosphere; Green chemistry

5: sodium tetrahydroborate / methanol

With hydrogenchloride; sodium tetrahydroborate; hydroxylamine hydrochloride; sodium cyanoborohydride; sodium sulfate; sodium hydroxide; In methanol; nitromethane; ethanol; dichloromethane; water;

DOI:10.1002/adsc.201300624

upstream raw materials:

Benzaldoxime

N-benzyl hydroxylalmine

benzaldehyde