(1′S,5α,6R,7R,14α)-1′-(4,5-epoxy-7,8-dihydro-3-hydroxy-6-methoxy-17-cyclopropylmethyl-6,14-ethanomorphinan-7-yl)-1′-(4-(2-propyl)phenyl)ethan-1′-ol

Base Information

Chemical Name:(1′S,5α,6R,7R,14α)-1′-(4,5-epoxy-7,8-dihydro-3-hydroxy-6-methoxy-17-cyclopropylmethyl-6,14-ethanomorphinan-7-yl)-1′-(4-(2-propyl)phenyl)ethan-1′-ol
CAS No.:1417783-65-3
Molecular Formula:C₃₄H₄₃NO₄
Molecular Weight:529.72
Hs Code.:

(1′S,5α,6R,7R,14α)-1′-(4,5-epoxy-7,8-dihydro-3-hydroxy-6-methoxy-17-cyclopropylmethyl-6,14-ethanomorphinan-7-yl)-1′-(4-(2-propyl)phenyl)ethan-1′-ol

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Chemical Property of (1′S,5α,6R,7R,14α)-1′-(4,5-epoxy-7,8-dihydro-3-hydroxy-6-methoxy-17-cyclopropylmethyl-6,14-ethanomorphinan-7-yl)-1′-(4-(2-propyl)phenyl)ethan-1′-ol

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Technology Process of (1′S,5α,6R,7R,14α)-1′-(4,5-epoxy-7,8-dihydro-3-hydroxy-6-methoxy-17-cyclopropylmethyl-6,14-ethanomorphinan-7-yl)-1′-(4-(2-propyl)phenyl)ethan-1′-ol

There total 3 articles about (1′S,5α,6R,7R,14α)-1′-(4,5-epoxy-7,8-dihydro-3-hydroxy-6-methoxy-17-cyclopropylmethyl-6,14-ethanomorphinan-7-yl)-1′-(4-(2-propyl)phenyl)ethan-1′-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18620-03-6
4-isopropylphenylmagnesium bromide

: 152427-77-5
(5R,6R,7S,9R,13S,14S)-7-Acetyl-17-cyclopropylmethyl-4,5-epoxy-18,19-dihydro-3,6-dimethoxy-6,14-ethanomorphinan

: 1417783-65-3
(1′S,5α,6R,7R,14α)-1′-(4,5-epoxy-7,8-dihydro-3-hydroxy-6-methoxy-17-cyclopropylmethyl-6,14-ethanomorphinan-7-yl)-1′-(4-(2-propyl)phenyl)ethan-1′-ol

Guidance literature:: Multi-step reaction with 2 steps

1: toluene; tetrahydrofuran / 20 h / 20 °C / Inert atmosphere

2: N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydride; 1-thiopropane / 3 h / Inert atmosphere; Heating

With N,N,N,N,N,N-hexamethylphosphoric triamide; 1-thiopropane; sodium hydride; In tetrahydrofuran; toluene;
DOI:10.1021/jm401964y

Reference yield:

: C₃₅H₄₅NO₄

: 1417783-65-3
(1′S,5α,6R,7R,14α)-1′-(4,5-epoxy-7,8-dihydro-3-hydroxy-6-methoxy-17-cyclopropylmethyl-6,14-ethanomorphinan-7-yl)-1′-(4-(2-propyl)phenyl)ethan-1′-ol

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; 1-thiopropane; sodium hydride; for 3h; Inert atmosphere; Heating;
DOI:10.1021/jm401964y