18620-03-6

Usage

Uses

Used in Organic Synthesis:
4-Iso-Propylphenylmagnesium bromide is used as a reagent for the synthesis of a wide range of organic compounds. Its high reactivity and nucleophilic nature make it a versatile agent in the formation of carbon-carbon bonds through the Grignard reaction.
Used in Pharmaceutical Industry:
4-Iso-Propylphenylmagnesium bromide is used as a precursor in the preparation of various pharmaceuticals. Its ability to form carbon-carbon bonds in organic synthesis contributes to the development of new drug molecules with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 4-Iso-Propylphenylmagnesium bromide is utilized as a precursor for the synthesis of agrochemicals, including pesticides and other crop protection agents. Its role in organic synthesis aids in the development of effective and environmentally friendly agrochemical products.
Used in Fine Chemicals Industry:
4-Iso-Propylphenylmagnesium bromide is also employed in the synthesis of fine chemicals, which are high-purity chemicals used in various applications such as fragrances, dyes, and specialty chemicals. Its versatility in organic synthesis enables the production of high-quality fine chemicals with specific properties and applications.

InChI:InChI=1/C9H11.BrH.Mg/c1-8(2)9-6-4-3-5-7-9;;/h4-8H,1-2H3;1H;/q;;+1/p-1/rC9H11BrMg/c1-7(2)8-3-5-9(11-10)6-4-8/h3-7H,1-2H3

Upstream product

• 586-61-8 4-iso-propylbromobenzene 
• 7439-95-4 magnesium 

Downstream Products

• 10099-57-7 2-(4-isopropylphenyl)ethanol 
• 536-60-7 cuminol 
• 18027-97-9 Trimethyl-(2-isopropylphenyl)silane 
• 118021-43-5 bis-(4-isopropyl-phenyl)-sulfoxide 
• 536-66-3 p-isopropylbenzoic acid 
• 109962-15-4 4-deuterocumene 
• 22543-72-2 (+/-)-(4-isopropylphenyl)phenylmethanol 
• 4397-08-4 1-(4-isopropylphenyl)propan-1-ol 
• 26667-63-0 5-(4-isopropyl-phenyl)-5-methyl-dihydro-furan-2-one 
• 35364-90-0 4-isopropyl-benzaldehyde diethylacetal 
• 122-03-2 (4-isopropylbenzaldehyde) 
• 3897-64-1 1-allyl-4-isopropylbenzene 
• 645-13-6 4-isopropylacetophenone 
• 10277-88-0 1,1,1-tris(4-isopropylphenyl)methanol 

Relevant academic research and scientific papers

Facile Hydrogenolysis of C(sp3)–C(sp3) σ Bonds

The modification of benzylic quaternary, tertiary, and secondary carbon centers through palladium-catalyzed hydrogenolysis of C(sp3)–C(sp3) σ bonds is presented. When benzyl Meldrum's acid derivatives bearing quaternary benzylic centers are treated under mild hydrogenolysis conditions – palladium on carbon and atmospheric pressure of hydrogen – aromatics substituted with tertiary benzylic centers and Meldrum's acid are obtained with good to excellent yield. Analogously, substrates containing tertiary or secondary benzylic centers yield aromatics substituted with secondary benzylic centers or toluene derivatives, respectively. Furthermore, this strategy is used for the high yielding synthesis of diarylmethanes. The scope of the reductive dealkylation reaction is explored and the limitations with respect to steric and electronic factors are determined. A mechanistic analysis of the reaction is described that consisted of deuterium labelling experiments and hydrogenolysis of enantioenriched derivatives. The investigation shows that the C(sp3)–C(sp3) σ bond-cleaving events occur through a hybrid SN1/SN2 mechanism, in which the palladium center displaces a carbon-based leaving group, namely Meldrum's acid, with inversion of configuration, followed by reductive elimination of palladium to furnish a C?H bond. (Figure presented.).

BENZOQUINAZOLINE DERIVATIVES AND THEIR USE IN TREATING BONE DISORDERS

A compound of formula (I) or a pharmaceutically acceptable salt or prodrug ester thereof, wherein the groups R2, R3, R4, Q, X and Y are as defined in the specification, is useful in the treatment of bone conditions related to increased calcium depletion or resorption.