discoipyrrole D

Base Information

Chemical Name:discoipyrrole D
CAS No.:1452507-32-2
Molecular Formula:C₃₈H₃₄N₂O₇
Molecular Weight:630.697
Hs Code.:

Synonyms:

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Chemical Property of discoipyrrole D

Chemical Property:

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Technology Process of discoipyrrole D

There total 14 articles about discoipyrrole D which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (E)-3-(3a-isobutyl-1,2-bis(4-(methoxymethoxy)phenyl)-3,5-dioxo-3,3a-dihydro-5H-benzo[d]pyrrole[2,1][1,3]oxazin-7-yl)acrylaldehyde

: 1452507-32-2
discoipyrrole D

Guidance literature:: Multi-step reaction with 3 steps

1.1: C₃₄H₁₂F₁₄O₂ / toluene / 48 h / 80 °C / Inert atmosphere; Molecular sieve; Sealed tube

2.1: Nitrosobenzene; D-Prolin / acetonitrile / 6 h / 4 °C / Inert atmosphere

2.2: 16 h / 22 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 2 h / 22 °C / Inert atmosphere

3.2: 3 h / 22 °C / Inert atmosphere

With C₃₄H₁₂F₁₄O₂; Nitrosobenzene; trifluoroacetic acid; D-Prolin; In dichloromethane; toluene; acetonitrile;
DOI:10.1021/acs.joc.7b01192

Reference yield:

: 181765-86-6
5-bromo-2-iodo-benzoic acid methyl ester

: 1452507-32-2
discoipyrrole D

Guidance literature:: Multi-step reaction with 13 steps

1.1: copper(l) iodide; 1,10-Phenanthroline; caesium carbonate / toluene / 48 h / 100 °C / Inert atmosphere

2.1: trichlorophosphate / tetrahydrofuran / 3.75 h / 0 - 22 °C / Inert atmosphere

3.1: silver trifluoroacetate; iodine / tetrahydrofuran / 16 h / 0 - 22 °C / Inert atmosphere

4.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / acetonitrile; water / 48 h / 60 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 22 °C / Inert atmosphere

6.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

6.2: -78 °C / Inert atmosphere

7.1: platinum(IV) oxide hydrate; hydrogen / tetrahydrofuran / 48 h / 22 °C

8.1: tetrabutylammonium acetate; potassium carbonate; potassium chloride; palladium diacetate / N,N-dimethyl-formamide / 48 h / 100 °C / Inert atmosphere; Sealed tube

9.1: potassium hydroxide / tetrahydrofuran; water; ethanol / 24 h / 22 °C / Inert atmosphere

10.1: MoOPH / methanol / 16 h / 22 °C / Inert atmosphere

11.1: C₃₄H₁₂F₁₄O₂ / toluene / 48 h / 80 °C / Inert atmosphere; Molecular sieve; Sealed tube

12.1: Nitrosobenzene; D-Prolin / acetonitrile / 6 h / 4 °C / Inert atmosphere

12.2: 16 h / 22 °C / Inert atmosphere

13.1: trifluoroacetic acid / dichloromethane / 2 h / 22 °C / Inert atmosphere

13.2: 3 h / 22 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; 1,10-Phenanthroline; platinum(IV) oxide hydrate; C₃₄H₁₂F₁₄O₂; potassium chloride; hydrogen; iodine; tetrabutylammonium acetate; palladium diacetate; silver trifluoroacetate; sodium carbonate; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; Nitrosobenzene; trifluoroacetic acid; D-Prolin; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; 1.1: |Ullmann-Goldberg Substitution / 2.1: |Vilsmeier-Haack Formylation / 4.1: |Suzuki-Miyaura Coupling / 6.1: |Wittig Olefination / 6.2: |Wittig Olefination / 8.1: |Heck Reaction;
DOI:10.1021/acs.joc.7b01192

Reference yield:

: methyl 5-bromo-2-(5-formyl-2,3-bis(4-(methoxymethoxy)-phenyl)-1H-pyrrol-1-yl)benzoate

: 1452507-32-2
discoipyrrole D

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: -78 °C / Inert atmosphere

2.1: platinum(IV) oxide hydrate; hydrogen / tetrahydrofuran / 48 h / 22 °C

3.1: tetrabutylammonium acetate; potassium carbonate; potassium chloride; palladium diacetate / N,N-dimethyl-formamide / 48 h / 100 °C / Inert atmosphere; Sealed tube

4.1: potassium hydroxide / tetrahydrofuran; water; ethanol / 24 h / 22 °C / Inert atmosphere

5.1: MoOPH / methanol / 16 h / 22 °C / Inert atmosphere

6.1: C₃₄H₁₂F₁₄O₂ / toluene / 48 h / 80 °C / Inert atmosphere; Molecular sieve; Sealed tube

7.1: Nitrosobenzene; D-Prolin / acetonitrile / 6 h / 4 °C / Inert atmosphere

7.2: 16 h / 22 °C / Inert atmosphere

8.1: trifluoroacetic acid / dichloromethane / 2 h / 22 °C / Inert atmosphere

8.2: 3 h / 22 °C / Inert atmosphere

With n-butyllithium; platinum(IV) oxide hydrate; C₃₄H₁₂F₁₄O₂; potassium chloride; hydrogen; tetrabutylammonium acetate; palladium diacetate; potassium carbonate; Nitrosobenzene; trifluoroacetic acid; D-Prolin; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; 1.1: |Wittig Olefination / 1.2: |Wittig Olefination / 3.1: |Heck Reaction;
DOI:10.1021/acs.joc.7b01192