181765-86-6Relevant articles and documents
Transition-Metal-Free Synthesis of Phenanthridinones through Visible-Light-Driven Oxidative C–H Amidation
Usami, Kaoru,Yamaguchi, Eiji,Tada, Norihiro,Itoh, Akichika
, p. 1496 - 1504 (2019/06/27)
The treatment of N-aryl biphenylcarboxamide, 1-chloroanthraquinone (1-Cl-AQN) catalyst, and K2CO3 in CHCl3 under visible light irradiation affords phenanthridinone via radical cyclization. This reaction proceeds under transition-metal-free condition, room temperature, and direct C–H amidation. Mechanistic studies indicate that amidyl radical generation proceeds by visible light induced proton coupled electron transfer (PCET) from N–H bond of the amide.
Analogues of acetylene phenolic natural product as well as preparation method and application of analogues
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Paragraph 0104-0106, (2019/08/06)
The invention belongs to the technical field of drugs and chemical engineering, and discloses analogues of an acetylene phenolic natural product as well as a preparation method and application of theanalogues. The analogues of the acetylene phenolic natural product prepared by the invention have remarkable inhibiting effect on a hypoxia-inducible factor HIF-1, and partial chemical compounds showsremarkable anti-proliferation effect to cancer cells; the chemical compounds and pharmaceutically acceptable salts thereof have wide application space in preparing anti-tumor drugs and HIF-1 inhibitors.
ETHYNYL COMPOUNDS, THEIR PREPARATION AND THEIR THERAPEUTIC USE FOR THE TREATMENT OF MALARIA
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Page/Page column 35, (2019/01/21)
The present disclosure relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein R1 means a fluorine atom or a perhalogeno linear alkyl radical containing 1, 2 or 3 carbon atoms; R2 means a chlorine atom, a linear alkyl radical containing 1, 2 or 3 carbon atoms or a perhalogeno linear alkyl radical containing 1, 2 or 3 carbon atoms, and R means a hydrogen atom or a radical of formula (la). The present disclosure also relates to processes for their preparation as well their therapeutic uses, in particular such as for use in the treatment of malaria.
