Technology Process of bis(triphenylphosphine)(3’,4’-dimethoxy-[1,1’-biphenyl]-2-yl)palladium(II) bromine
There total 8 articles about bis(triphenylphosphine)(3’,4’-dimethoxy-[1,1’-biphenyl]-2-yl)palladium(II) bromine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
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Multi-step reaction with 8 steps
1.1: N-Bromosuccinimide; silica gel / dichloromethane / 24 h / 20 °C
2.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere
2.2: -78 - 20 °C / Inert atmosphere
3.1: hydrogenchloride / tetrahydrofuran; water / -20 - 20 °C / Inert atmosphere
4.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; ethanol / 24 h / Inert atmosphere; Reflux
5.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere
5.2: -78 - 20 °C / Inert atmosphere
6.1: hydrogenchloride / tetrahydrofuran; water / -20 - 20 °C / Inert atmosphere
7.1: N-Bromosuccinimide; silica gel / ethanol / 12 h / 20 °C
8.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / 1,2-dimethoxyethane / 10 h / Schlenk technique; Inert atmosphere; Reflux
With
hydrogenchloride; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium(0); n-butyllithium; silica gel; sodium carbonate; potassium carbonate;
In
tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; toluene;
4.1: |Suzuki Coupling / 8.1: |Suzuki Coupling;
DOI:10.1002/hlca.201200485
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: hydrogenchloride / tetrahydrofuran; water / -20 - 20 °C / Inert atmosphere
2.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; ethanol / 24 h / Inert atmosphere; Reflux
3.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere
3.2: -78 - 20 °C / Inert atmosphere
4.1: hydrogenchloride / tetrahydrofuran; water / -20 - 20 °C / Inert atmosphere
5.1: N-Bromosuccinimide; silica gel / ethanol / 12 h / 20 °C
6.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / 1,2-dimethoxyethane / 10 h / Schlenk technique; Inert atmosphere; Reflux
With
hydrogenchloride; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium(0); n-butyllithium; silica gel; sodium carbonate; potassium carbonate;
In
tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; toluene;
2.1: |Suzuki Coupling / 6.1: |Suzuki Coupling;
DOI:10.1002/hlca.201200485
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: hydrogenchloride / tetrahydrofuran; water / -20 - 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; ethanol / 24 h / Inert atmosphere; Reflux
4.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere
4.2: -78 - 20 °C / Inert atmosphere
5.1: hydrogenchloride / tetrahydrofuran; water / -20 - 20 °C / Inert atmosphere
6.1: N-Bromosuccinimide; silica gel / ethanol / 12 h / 20 °C
7.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / 1,2-dimethoxyethane / 10 h / Schlenk technique; Inert atmosphere; Reflux
With
hydrogenchloride; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium(0); n-butyllithium; silica gel; sodium carbonate; potassium carbonate;
In
tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; toluene;
3.1: |Suzuki Coupling / 7.1: |Suzuki Coupling;
DOI:10.1002/hlca.201200485
