3⁽⁵⁾-ferrocenylpyrazole

Base Information

• Chemical Name: 3⁽⁵⁾-ferrocenylpyrazole
• CAS No.: 1291-56-1
• Molecular Formula: C₁₃H₁₂FeN₂
• Molecular Weight: 252.099
• Mol file: 1291-56-1.mol

Synonyms:

Chemical Property of 3⁽⁵⁾-ferrocenylpyrazole

Chemical Property:

Purity/Quality:

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Technology Process of 3⁽⁵⁾-ferrocenylpyrazole

There total 1 articles about 3⁽⁵⁾-ferrocenylpyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

(1-chloro-2-formylvinyl)ferrocene (12085-68-6) + 4-hydroxybenzoic acid hydrazide (5351-23-5) → 3(5)-ferrocenylpyrazole (1291-56-1) + (3-ferrocenylpyrazol-1-yl)(4-hydroxyphenyl)methanone (956103-49-4)

Guidance literature:

In 1,4-dioxane; hydrazine (3 equiv.) was added to soln. of Fe complex in dioxane under Ar; mixt. was stirred at room temp. for 2.5 h; refluxed for 6 h; cooled to 25°C; solvent removed (vac.); dissolved in H2O; extd. (CHCl3); org. phase dried (MgSO4); evapd. (vac.); chromd. (silica gel, hexane/EtOAc, 19/1 to 1/1);

DOI:10.1016/j.jorganchem.2007.07.029

upstream raw materials:

(1-chloro-2-formylvinyl)ferrocene

4-hydroxybenzoic acid hydrazide