(6aR,9aS)-5,6a,7,8,9,9a-hexahydro-2-(4-(6-fluoropyridin-2-yl)benzyl)-5-methyl-3-(4-fluorophenoxy)cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one

Base Information

Chemical Name:(6aR,9aS)-5,6a,7,8,9,9a-hexahydro-2-(4-(6-fluoropyridin-2-yl)benzyl)-5-methyl-3-(4-fluorophenoxy)cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one
CAS No.:1351961-51-7
Molecular Formula:C₂₉H₂₄F₂N₆O₂
Molecular Weight:526.545
Hs Code.:

(6aR,9aS)-5,6a,7,8,9,9a-hexahydro-2-(4-(6-fluoropyridin-2-yl)benzyl)-5-methyl-3-(4-fluorophenoxy)cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one

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Chemical Property of (6aR,9aS)-5,6a,7,8,9,9a-hexahydro-2-(4-(6-fluoropyridin-2-yl)benzyl)-5-methyl-3-(4-fluorophenoxy)cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one

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Technology Process of (6aR,9aS)-5,6a,7,8,9,9a-hexahydro-2-(4-(6-fluoropyridin-2-yl)benzyl)-5-methyl-3-(4-fluorophenoxy)cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one

There total 7 articles about (6aR,9aS)-5,6a,7,8,9,9a-hexahydro-2-(4-(6-fluoropyridin-2-yl)benzyl)-5-methyl-3-(4-fluorophenoxy)cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1351961-59-5,916764-91-5
7-(4-methoxybenzyl)-5-methyl-2,7-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4,6(5H)-dione

: 1351961-51-7
(6aR,9aS)-5,6a,7,8,9,9a-hexahydro-2-(4-(6-fluoropyridin-2-yl)benzyl)-5-methyl-3-(4-fluorophenoxy)cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 25 °C / Inert atmosphere

2.1: trifluoroacetic acid; trifluorormethanesulfonic acid / dichloromethane / 25 °C / Inert atmosphere

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / tetrahydrofuran / 0.42 h / 25 °C / Inert atmosphere

3.2: 25 °C / Inert atmosphere

4.1: N,N-dimethyl-formamide; thionyl chloride / 1 h / 25 °C / Inert atmosphere

5.1: lithium hexamethyldisilazane; hexachloroethane / dichloromethane; tetrahydrofuran / 1.5 h / 25 °C / Inert atmosphere

6.1: potassium carbonate / 1,4-dioxane / 3 h / 150 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With thionyl chloride; hexachloroethane; trifluorormethanesulfonic acid; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.5b01751

Reference yield:

: 1520918-63-1
2-(4-(6-fluoropyridin-2-yl)benzyl)-7-(4-methoxybenzyl)-5-methyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

: 1351961-51-7
(6aR,9aS)-5,6a,7,8,9,9a-hexahydro-2-(4-(6-fluoropyridin-2-yl)benzyl)-5-methyl-3-(4-fluorophenoxy)cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid; trifluorormethanesulfonic acid / dichloromethane / 25 °C / Inert atmosphere

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / tetrahydrofuran / 0.42 h / 25 °C / Inert atmosphere

2.2: 25 °C / Inert atmosphere

3.1: N,N-dimethyl-formamide; thionyl chloride / 1 h / 25 °C / Inert atmosphere

4.1: lithium hexamethyldisilazane; hexachloroethane / dichloromethane; tetrahydrofuran / 1.5 h / 25 °C / Inert atmosphere

5.1: potassium carbonate / 1,4-dioxane / 3 h / 150 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With thionyl chloride; hexachloroethane; trifluorormethanesulfonic acid; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/acs.jmedchem.5b01751

Reference yield:

: 1351960-86-5
2-(4-(6-fluoropyridin-2-yl)benzyl)-5-methyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

: 1351961-51-7
(6aR,9aS)-5,6a,7,8,9,9a-hexahydro-2-(4-(6-fluoropyridin-2-yl)benzyl)-5-methyl-3-(4-fluorophenoxy)cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / tetrahydrofuran / 0.42 h / 25 °C / Inert atmosphere

1.2: 25 °C / Inert atmosphere

2.1: N,N-dimethyl-formamide; thionyl chloride / 1 h / 25 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane; hexachloroethane / dichloromethane; tetrahydrofuran / 1.5 h / 25 °C / Inert atmosphere

4.1: potassium carbonate / 1,4-dioxane / 3 h / 150 °C / Inert atmosphere; Sealed tube; Microwave irradiation

With thionyl chloride; hexachloroethane; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/acs.jmedchem.5b01751