Phosphonic acid, [4-[(6-amino-9H-purin-9-yl)oxy]-3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy] methyl]-1-butenyl]-, bis(1-methylethyl) ester, (E)-

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Chemical Name:Phosphonic acid, [4-[(6-amino-9H-purin-9-yl)oxy]-3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy] methyl]-1-butenyl]-, bis(1-methylethyl) ester, (E)-
CAS No.:140896-69-1
Molecular Formula:C32H44N5O5PSi
Molecular Weight:637.791
Hs Code.:

Synonyms:

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Chemical Property of Phosphonic acid, [4-[(6-amino-9H-purin-9-yl)oxy]-3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy] methyl]-1-butenyl]-, bis(1-methylethyl) ester, (E)-

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Technology Process of Phosphonic acid, [4-[(6-amino-9H-purin-9-yl)oxy]-3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy] methyl]-1-butenyl]-, bis(1-methylethyl) ester, (E)-

There total 8 articles about Phosphonic acid, [4-[(6-amino-9H-purin-9-yl)oxy]-3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy] methyl]-1-butenyl]-, bis(1-methylethyl) ester, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 60-34-4
methylhydrazine

: 140896-68-0
(E)-9-<<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-4-(diisopropoxyphosphoryl)but-3-enyl>oxy>-6-N-phthalimidopurine

: 140896-69-1
(E)-9-<<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-4-(diisopropoxyphosphoryl)but-3-enyl>oxy>adenine

Guidance literature:: In acetone hexane; dichloromethane;

Reference yield: 74.0%

: 140896-68-0
(E)-9-<<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-4-(diisopropoxyphosphoryl)but-3-enyl>oxy>-6-N-phthalimidopurine

: 140896-69-1
(E)-9-<<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-4-(diisopropoxyphosphoryl)but-3-enyl>oxy>adenine

Guidance literature:: With methylhydrazine; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1021/jm00062a006

Reference yield:

: 1660-95-3
Tetraisopropyl methylenediphosphonate

: 140896-69-1
(E)-9-<<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-4-(diisopropoxyphosphoryl)but-3-enyl>oxy>adenine

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) n-butyllithium / 1.) n-hexane, n-heptane, RT, 15 min, 2.) n-hexane, n-heptane, RT, 15 min

2: 63 percent / HCl / methanol / 1.5 h / Ambient temperature

3: 85 percent / p-toluenesulfonic acid monohydrate / tetrahydrofuran; H₂O / 2 h / Ambient temperature

4: 94 percent / imidazole / tetrahydrofuran / 3 h / Ambient temperature

5: 74 percent / potassium carbonate, methanol / 5 h / Ambient temperature

6: 62 percent / PPh₃, DEAD / tetrahydrofuran / 18 h / Ambient temperature

7: 74 percent / methylhydrazine / CH₂Cl₂ / 1 h / Ambient temperature

With 1H-imidazole; hydrogenchloride; methanol; n-butyllithium; potassium carbonate; toluene-4-sulfonic acid; triphenylphosphine; methylhydrazine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm00062a006