Technology Process of Phosphonic acid,
[4-(6-azido-9H-purin-9-yl)-3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl
]-1-butenyl]-, bis(1-methylethyl) ester, (E)-
There total 7 articles about Phosphonic acid,
[4-(6-azido-9H-purin-9-yl)-3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl
]-1-butenyl]-, bis(1-methylethyl) ester, (E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium azide;
In
N,N-dimethyl-formamide;
at 70 ℃;
for 2.8h;
DOI:10.1021/jm00062a006
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) n-butyllithium / 1.) n-hexane, n-heptane, RT, 15 min, 2.) n-hexane, n-heptane, RT, 15 min
2: 63 percent / HCl / methanol / 1.5 h / Ambient temperature
3: 85 percent / p-toluenesulfonic acid monohydrate / tetrahydrofuran; H2O / 2 h / Ambient temperature
4: 94 percent / imidazole / tetrahydrofuran / 3 h / Ambient temperature
5: 74 percent / potassium carbonate, methanol / 5 h / Ambient temperature
6: 28 percent / PPh3, DEAD / dimethylformamide / 16 h / Ambient temperature
7: 75 percent / sodium azide / dimethylformamide / 2.8 h / 70 °C
With
1H-imidazole; hydrogenchloride; methanol; n-butyllithium; sodium azide; potassium carbonate; toluene-4-sulfonic acid; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00062a006
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 85 percent / p-toluenesulfonic acid monohydrate / tetrahydrofuran; H2O / 2 h / Ambient temperature
2: 94 percent / imidazole / tetrahydrofuran / 3 h / Ambient temperature
3: 74 percent / potassium carbonate, methanol / 5 h / Ambient temperature
4: 28 percent / PPh3, DEAD / dimethylformamide / 16 h / Ambient temperature
5: 75 percent / sodium azide / dimethylformamide / 2.8 h / 70 °C
With
1H-imidazole; methanol; sodium azide; potassium carbonate; toluene-4-sulfonic acid; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00062a006
