140896-70-4

Upstream product

• 87-42-3 6-chloropurine 
• 603-35-0 triphenylphosphine 
• 148120-72-3 diisopropyl <(E)-3-<<(tert-butyldiphenylsilyl)oxy>methyl>4-hydroxybut-1-enyl>phosphonate 
• 1972-28-7 diethylazodicarboxylate 
• 140896-57-7 diisopropyl <(E)-3-(acetoxymethyl)-4-<(tert-butyldiphenylsilyl)oxy>but-1-enyl>phosphonate 
• 148120-71-2 diisopropyl <(E)-2-(2,2-dimethyl-1,3-dioxan-5-yl)ethenyl>phosphonate 
• 140896-56-6 diisopropyl <(E)-3-(acetoxymethyl)-4-hydroxybut-1-enyl>phosphonate 
• 140896-55-5 diisopropyl <(E)-4-hydroxy-3-(hydroxymethyl)but-1enyl>phosphonate 
• 1660-95-3 Tetraisopropyl methylenediphosphonate 

Downstream Products

• 148120-77-8 [(E)-3-(6-Amino-purin-9-ylmethyl)-4-(tert-butyl-diphenyl-silanyloxy)-but-1-enyl]-phosphonic acid diisopropyl ester 
• 140896-71-5 (E)-6-azido-9-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-4-(diisopropoxyphosphoryl)but-3-enyl>purine 

Relevant academic research and scientific papers

Antiviral phosphono-alken derivatives of purines

The present invention provides antiviral compounds of Formula (I), and pharmaceutically acceptable salts thereof: STR1 wherein X is --CH2 O or --CH2 ; R1 is hydroxy or amino; R2 is hydrogen or amino; R3/su

Novel acyclonucleotides: Synthesis and antiviral activity of alkenylphosphonic acid derivatives of purines and a pyrimidine

A series of phosphonoalkenyl and (phosphonoalkenyl)oxy derivatives of purines and a pyrimidine were synthesized. These compounds are the first reported acyclonucleotides which incorporate the α,β-unsaturated phosphonic acid moiety as the phosphate mimic and include compounds in which the acyclic substituent is attached to N-9 of a purine or N-1 of a pyrimidine by either a nitrogen-carbon or a nitrogen-oxygen bond. The phosphonoalkenyl-substituted compounds 7a-c, 8a-c, 9, 10, and 12 were prepared either by Mitsunobu coupling of alcohols with purine or pyrimidine derivatives or by alternative alkylations of the heterocyclic bases. The (phosphonoalkenyl)oxy derivatives 7d-g, 8d-g, and 11 were synthesized by coupling of alcohols with 9- hydroxypurines or a 1-hydroxypyrimidine under Mitsunobu conditions. The novel acyclonucleotides were tested for activity against herpes simplex types 1 and 2 (HSV-1 and HSV-2), varicella zoster virus (VZV), cytomegalovirus (CMV), visna virus, and human immunodeficiency virus type 1 (HIV-1). Guanine derivatives were moderately to extremely cytotoxic, but the adenines were less toxic to cells. At the concentrations tested, (Z)-isomers in the unbranched series had no activity against herpes viruses or HIV-1. (E)-9- [(4-Phosphonobut-3-enyl)oxy]adenine (7d) displayed selective activity against HIV-1, (E)-2,6-diamino-9-(4-phosphonobut-3-enyl)purine (9) showed selective antiretrovirus activity, and (E)-9-[2-(hydroxymethyl)-4-phosphonobut-3- enyl]adenine (7c) showed selective antiherpesvirus (VZV and CMV) activity.