benzyl (2Z)-2-[1-ethoxy-2-hydroxy-2-(4-methylphenyl)propylidene]hydrazinecarboxylate

Base Information

• Chemical Name: benzyl (2Z)-2-[1-ethoxy-2-hydroxy-2-(4-methylphenyl)propylidene]hydrazinecarboxylate
• CAS No.: 1352808-82-2
• Molecular Formula: C₂₀H₂₄N₂O₄
• Molecular Weight: 356.422
• Mol file: 1352808-82-2.mol

Synonyms:

Chemical Property of benzyl (2Z)-2-[1-ethoxy-2-hydroxy-2-(4-methylphenyl)propylidene]hydrazinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl (2Z)-2-[1-ethoxy-2-hydroxy-2-(4-methylphenyl)propylidene]hydrazinecarboxylate

There total 3 articles about benzyl (2Z)-2-[1-ethoxy-2-hydroxy-2-(4-methylphenyl)propylidene]hydrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-hydroxy-2-(4-methylphenyl)propanimidoate hydrochloride (947-43-3) → benzyl (2E)-2-[1-ethoxy-2-hydroxy-2-(4-methylphenyl)propylidene]hydrazinecarboxylate (1352808-18-4) + benzyl (2Z)-2-[1-ethoxy-2-hydroxy-2-(4-methylphenyl)propylidene]hydrazinecarboxylate (1352808-82-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; hydrogen sulfide / dichloromethane / 1 h / 5 - 20 °C

2: ethyl acetate / 20 °C

With pyridine; hydrogen sulfide; In dichloromethane; ethyl acetate;

DOI:10.1002/ardp.201000346

Reference yield:

2-hydroxy-2-methyl-2-(4'-methylphenyl)acetonitrile (69813-74-7) → benzyl (2E)-2-[1-ethoxy-2-hydroxy-2-(4-methylphenyl)propylidene]hydrazinecarboxylate (1352808-18-4) + benzyl (2Z)-2-[1-ethoxy-2-hydroxy-2-(4-methylphenyl)propylidene]hydrazinecarboxylate (1352808-82-2)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / diethyl ether / 120 h / -10 - 0 °C

2: pyridine; hydrogen sulfide / dichloromethane / 1 h / 5 - 20 °C

3: ethyl acetate / 20 °C

With pyridine; hydrogenchloride; hydrogen sulfide; In diethyl ether; dichloromethane; ethyl acetate; 1: Pinner amidine synthesis;

DOI:10.1002/ardp.201000346

Reference yield:

N-benzyloxycarbonyl-hydrazine (5331-43-1) + O-ethyl 2-hydroxy-2-(4-methylphenyl)propanethioate (1352808-52-6) → benzyl (2E)-2-[1-ethoxy-2-hydroxy-2-(4-methylphenyl)propylidene]hydrazinecarboxylate (1352808-18-4) + benzyl (2Z)-2-[1-ethoxy-2-hydroxy-2-(4-methylphenyl)propylidene]hydrazinecarboxylate (1352808-82-2)

Guidance literature:

In ethyl acetate; at 20 ℃; optical yield given as %de;

DOI:10.1002/ardp.201000346

upstream raw materials:

ethyl 2-hydroxy-2-(4-methylphenyl)propanimidoate hydrochloride

N-benzyloxycarbonyl-hydrazine

O-ethyl 2-hydroxy-2-(4-methylphenyl)propanethioate

2-hydroxy-2-methyl-2-(4'-methylphenyl)acetonitrile