ethyl 2-hydroxy-2-(4-methylphenyl)propanimidoate hydrochloride

Base Information

• Chemical Name: ethyl 2-hydroxy-2-(4-methylphenyl)propanimidoate hydrochloride
• CAS No.: 947-43-3
• Molecular Formula: C₁₂H₁₇NO₂*ClH
• Molecular Weight: 243.733
• Mol file: 947-43-3.mol

Synonyms:ethyl 2-hydroxy-2-(4-methylphenyl)propanimidoate hydrochloride

Chemical Property of ethyl 2-hydroxy-2-(4-methylphenyl)propanimidoate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-hydroxy-2-(4-methylphenyl)propanimidoate hydrochloride

There total 1 articles about ethyl 2-hydroxy-2-(4-methylphenyl)propanimidoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

ethanol (64-17-5) + 2-hydroxy-2-methyl-2-(4'-methylphenyl)acetonitrile (69813-74-7) → ethyl 2-hydroxy-2-(4-methylphenyl)propanimidoate hydrochloride (947-43-3)

Guidance literature:

With hydrogenchloride; In diethyl ether; at -10 - 0 ℃; for 120h;

DOI:10.1002/ardp.201000346

Reference yield: 87.0%

ethyl 2-hydroxy-2-(4-methylphenyl)propanimidoate hydrochloride (947-43-3) → O-ethyl 2-hydroxy-2-(4-methylphenyl)propanethioate (1352808-52-6)

Guidance literature:

With pyridine; hydrogen sulfide; In dichloromethane; at 5 - 20 ℃; for 1h;

DOI:10.1002/ardp.201000346

Reference yield:

ethyl 2-hydroxy-2-(4-methylphenyl)propanimidoate hydrochloride (947-43-3) → C15H22N2O4

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; hydrogen sulfide / dichloromethane / 5 - 20 °C

2: ethyl acetate / 20 °C

With pyridine; hydrogen sulfide; In dichloromethane; ethyl acetate;

DOI:10.1055/s-0031-1290160

upstream raw materials:

ethanol

2-hydroxy-2-methyl-2-(4'-methylphenyl)acetonitrile

Downstream raw materials:

O-ethyl 2-hydroxy-2-(4-methylphenyl)propanethioate

5-ethoxy-6-methyl-6-(4-methylphenyl)-3,6-dihydro-2H-1,3,4-oxadiazin-2-one

benzyl (2E)-2-[1-ethoxy-2-hydroxy-2-(4-methylphenyl)propylidene]hydrazinecarboxylate

benzyl (2Z)-2-[1-ethoxy-2-hydroxy-2-(4-methylphenyl)propylidene]hydrazinecarboxylate