4-(2-methylphenyl)-1,2,3,6-tetrahydropyridine

Base Information

Chemical Name:4-(2-methylphenyl)-1,2,3,6-tetrahydropyridine
CAS No.:166401-49-6
Molecular Formula:C₁₂H₁₅N
Molecular Weight:173.258
Hs Code.:

Synonyms:

Suppliers and Price of 4-(2-methylphenyl)-1,2,3,6-tetrahydropyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1,2,3,6-TETRAHYDRO-4-(2-METHYLPHENYL)-PYRIDINE 95.00%
5MG
$ 505.58

Total 1 raw suppliers

Chemical Property of 4-(2-methylphenyl)-1,2,3,6-tetrahydropyridine

Chemical Property:

Boiling Point:288.3±29.0 °C(Predicted)
Density:0.994±0.06 g/cm3(Predicted)

Purity/Quality:: 1,2,3,6-TETRAHYDRO-4-(2-METHYLPHENYL)-PYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(2-methylphenyl)-1,2,3,6-tetrahydropyridine

There total 3 articles about 4-(2-methylphenyl)-1,2,3,6-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 166401-49-6
4-(2-methylphenyl)-1,2,3,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C

1.2: -78 - 20 °C

2.1: trifluoroacetic acid / 1 h / Reflux

With n-butyllithium; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1039/c6dt01461e

Reference yield:

: 16419-60-6
2-Methylphenylboronic acid

: 138647-49-1
4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 166401-49-6
4-(2-methylphenyl)-1,2,3,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water / 2 h / Reflux

2: trifluoroacetic acid / water; dichloromethane / 0.83 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; trifluoroacetic acid; lithium chloride; In dichloromethane; water; 1: |Suzuki Coupling;

Reference yield:

: 1-cyclopropyl-4-hydroxy-4-(2-methylphenyl)piperidine N-oxide

: 166401-49-6
4-(2-methylphenyl)-1,2,3,6-tetrahydropyridine

Guidance literature:: With hydrogenchloride; acetic acid; trifluoroacetic anhydride; Multistep reaction; 1.) 0 deg C;
DOI:10.1016/0040-4039(95)00693-7