(5S,11bR)-methyl 11-((3-(4-cyano-2,6-dimethylheptan-4-yl)-4-methoxyphenyl)sulfonyl)-9-((E)-3-ethoxy-3-oxoprop-1-en-1-yl)-3-oxo-2,3,5,6,11,11b-hexahydro-1H-indolizino[8,7-b]indole-5-carboxylate

Base Information

Chemical Name:(5S,11bR)-methyl 11-((3-(4-cyano-2,6-dimethylheptan-4-yl)-4-methoxyphenyl)sulfonyl)-9-((E)-3-ethoxy-3-oxoprop-1-en-1-yl)-3-oxo-2,3,5,6,11,11b-hexahydro-1H-indolizino[8,7-b]indole-5-carboxylate
CAS No.:1620580-69-9
Molecular Formula:C₃₈H₄₅N₃O₈S
Molecular Weight:703.857
Hs Code.:

(5S,11bR)-methyl 11-((3-(4-cyano-2,6-dimethylheptan-4-yl)-4-methoxyphenyl)sulfonyl)-9-((E)-3-ethoxy-3-oxoprop-1-en-1-yl)-3-oxo-2,3,5,6,11,11b-hexahydro-1H-indolizino[8,7-b]indole-5-carboxylate

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Chemical Property of (5S,11bR)-methyl 11-((3-(4-cyano-2,6-dimethylheptan-4-yl)-4-methoxyphenyl)sulfonyl)-9-((E)-3-ethoxy-3-oxoprop-1-en-1-yl)-3-oxo-2,3,5,6,11,11b-hexahydro-1H-indolizino[8,7-b]indole-5-carboxylate

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Technology Process of (5S,11bR)-methyl 11-((3-(4-cyano-2,6-dimethylheptan-4-yl)-4-methoxyphenyl)sulfonyl)-9-((E)-3-ethoxy-3-oxoprop-1-en-1-yl)-3-oxo-2,3,5,6,11,11b-hexahydro-1H-indolizino[8,7-b]indole-5-carboxylate

There total 4 articles about (5S,11bR)-methyl 11-((3-(4-cyano-2,6-dimethylheptan-4-yl)-4-methoxyphenyl)sulfonyl)-9-((E)-3-ethoxy-3-oxoprop-1-en-1-yl)-3-oxo-2,3,5,6,11,11b-hexahydro-1H-indolizino[8,7-b]indole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620581-27-2
C₁₇H₂₄ClNO₃S

: C₃₈H₄₅N₃O₈S

: 1620580-69-9
(5S,11bR)-methyl 11-((3-(4-cyano-2,6-dimethylheptan-4-yl)-4-methoxyphenyl)sulfonyl)-9-((E)-3-ethoxy-3-oxoprop-1-en-1-yl)-3-oxo-2,3,5,6,11,11b-hexahydro-1H-indolizino[8,7-b]indole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / 0 °C

1.2: 12 h / 0 - 23 °C

2.1: palladium diacetate; N-acetylglycine; silver(I) acetate / 24 h / 70 °C / Sealed tube

With silver(I) acetate; palladium diacetate; sodium hydride; N-acetylglycine; In tetrahydrofuran; mineral oil;
DOI:10.1021/ja505737x

Reference yield:

: 7035-03-2
2-methoxy-benzeneacetonitrile

: C₃₈H₄₅N₃O₈S

: 1620580-69-9
(5S,11bR)-methyl 11-((3-(4-cyano-2,6-dimethylheptan-4-yl)-4-methoxyphenyl)sulfonyl)-9-((E)-3-ethoxy-3-oxoprop-1-en-1-yl)-3-oxo-2,3,5,6,11,11b-hexahydro-1H-indolizino[8,7-b]indole-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 23 °C

2.1: chlorosulfonic acid / chloroform / 1.5 h / 0 - 23 °C

3.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / 0 °C

3.2: 12 h / 0 - 23 °C

4.1: palladium diacetate; N-acetylglycine; silver(I) acetate / 24 h / 70 °C / Sealed tube

With chlorosulfonic acid; silver(I) acetate; palladium diacetate; sodium hydride; N-acetylglycine; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ja505737x

Reference yield:

: 1620581-25-0
C₁₇H₂₅NO

: C₃₈H₄₅N₃O₈S

: 1620580-69-9
(5S,11bR)-methyl 11-((3-(4-cyano-2,6-dimethylheptan-4-yl)-4-methoxyphenyl)sulfonyl)-9-((E)-3-ethoxy-3-oxoprop-1-en-1-yl)-3-oxo-2,3,5,6,11,11b-hexahydro-1H-indolizino[8,7-b]indole-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: chlorosulfonic acid / chloroform / 1.5 h / 0 - 23 °C

2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / 0 °C

2.2: 12 h / 0 - 23 °C

3.1: palladium diacetate; N-acetylglycine; silver(I) acetate / 24 h / 70 °C / Sealed tube

With chlorosulfonic acid; silver(I) acetate; palladium diacetate; sodium hydride; N-acetylglycine; In tetrahydrofuran; chloroform; mineral oil;
DOI:10.1021/ja505737x