3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)-2-hydroxyphenethyl)-5-(4-(1-methylethoxy)phenyl)-5-methylimidazolidine-2,4-dione

Base Information

Chemical Name:3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)-2-hydroxyphenethyl)-5-(4-(1-methylethoxy)phenyl)-5-methylimidazolidine-2,4-dione
CAS No.:1198166-51-6
Molecular Formula:C₃₃H₃₄F₆N₂O₆
Molecular Weight:668.633
Hs Code.:

3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)-2-hydroxyphenethyl)-5-(4-(1-methylethoxy)phenyl)-5-methylimidazolidine-2,4-dione

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Chemical Property of 3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)-2-hydroxyphenethyl)-5-(4-(1-methylethoxy)phenyl)-5-methylimidazolidine-2,4-dione

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Technology Process of 3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)-2-hydroxyphenethyl)-5-(4-(1-methylethoxy)phenyl)-5-methylimidazolidine-2,4-dione

There total 8 articles about 3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)-2-hydroxyphenethyl)-5-(4-(1-methylethoxy)phenyl)-5-methylimidazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1198166-48-1
2-(benzyloxy)-4-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-n-propylphenoxy)-1-vinylbenzene

: 1198166-51-6
3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)-2-hydroxyphenethyl)-5-(4-(1-methylethoxy)phenyl)-5-methylimidazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: borane-THF / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 0 - 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

4.1: hydrogenchloride / ethyl acetate / 1 h / 0 - 20 °C

5.1: palladium on activated charcoal; hydrogen / methanol / 1 h

With hydrogenchloride; borane-THF; carbon tetrabromide; palladium on activated charcoal; hydrogen; potassium carbonate; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2016.05.048

Reference yield:

: 1198166-49-2
2-(2-(benzyloxy)-4-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-propyl-phenoxy)phenyl)ethan-1-ol

: 1198166-51-6
3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)-2-hydroxyphenethyl)-5-(4-(1-methylethoxy)phenyl)-5-methylimidazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; carbon tetrabromide / dichloromethane / 0 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3: hydrogenchloride / ethyl acetate / 1 h / 0 - 20 °C

4: palladium on activated charcoal; hydrogen / methanol / 1 h

With hydrogenchloride; carbon tetrabromide; palladium on activated charcoal; hydrogen; potassium carbonate; triphenylphosphine; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2016.05.048

Reference yield:

: 1198166-50-5
2-(benzyloxy)-1-(2-bromoethyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-n-propylphenoxy)benzene

: 1198166-51-6
3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)-2-hydroxyphenethyl)-5-(4-(1-methylethoxy)phenyl)-5-methylimidazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: hydrogenchloride / ethyl acetate / 1 h / 0 - 20 °C

3: palladium on activated charcoal; hydrogen / methanol / 1 h

With hydrogenchloride; palladium on activated charcoal; hydrogen; potassium carbonate; In methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2016.05.048