2-(benzyloxy)-1-(2-bromoethyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-n-propylphenoxy)benzene

Base Information

Chemical Name:2-(benzyloxy)-1-(2-bromoethyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-n-propylphenoxy)benzene
CAS No.:1198166-50-5
Molecular Formula:C₂₉H₂₉BrF₆O₄
Molecular Weight:635.441
Hs Code.:

Synonyms:2-(benzyloxy)-1-(2-bromoethyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-n-propylphenoxy)benzene

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Chemical Property of 2-(benzyloxy)-1-(2-bromoethyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-n-propylphenoxy)benzene

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Technology Process of 2-(benzyloxy)-1-(2-bromoethyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-n-propylphenoxy)benzene

There total 8 articles about 2-(benzyloxy)-1-(2-bromoethyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-n-propylphenoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1198166-49-2
2-(2-(benzyloxy)-4-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-propyl-phenoxy)phenyl)ethan-1-ol

: 1198166-50-5
2-(benzyloxy)-1-(2-bromoethyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-n-propylphenoxy)benzene

Guidance literature:: With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2016.05.048

Reference yield:

: 1198166-48-1
2-(benzyloxy)-4-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-n-propylphenoxy)-1-vinylbenzene

: 1198166-50-5
2-(benzyloxy)-1-(2-bromoethyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-n-propylphenoxy)benzene

Guidance literature:: Multi-step reaction with 2 steps

1.1: borane-THF / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 0 - 20 °C

With borane-THF; carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2016.05.048

Reference yield:

: 100-39-0
benzyl bromide

: 1198166-50-5
2-(benzyloxy)-1-(2-bromoethyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-n-propylphenoxy)benzene

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

3.1: acetic acid; iron / water / 4 h / 20 °C

4.1: potassium iodide; toluene-4-sulfonic acid; sodium nitrite / water; acetonitrile / 0 - 20 °C

5.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 80 °C / Microwave irradiation

6.1: borane-THF / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

6.2: 0 - 20 °C / Inert atmosphere

7.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 0 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; carbon tetrabromide; iron; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; acetic acid; triphenylphosphine; potassium iodide; sodium nitrite; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 5.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmc.2016.05.048