4-((6bR,10aS)-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)-1-(4-fluorophenyl)-1-butanone

Base Information

Chemical Name:4-((6bR,10aS)-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)-1-(4-fluorophenyl)-1-butanone
CAS No.:313368-82-0
Molecular Formula:C₂₃H₂₆FN₃O
Molecular Weight:379.477
Hs Code.:

Synonyms:

Suppliers and Price of 4-((6bR,10aS)-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)-1-(4-fluorophenyl)-1-butanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-((6bR,10aS)-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)-1-(4-fluorophenyl)-1-butanone

Chemical Property:

Purity/Quality:: >95% ^*data from raw suppliers

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Technology Process of 4-((6bR,10aS)-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)-1-(4-fluorophenyl)-1-butanone

There total 15 articles about 4-((6bR,10aS)-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)-1-(4-fluorophenyl)-1-butanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 313368-82-0
4-((6bR,10aS)-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)-1-(4-fluorophenyl)-1-butanone

Guidance literature:

Reference yield:

: 59564-59-9
1,2,3,4-tetrahydroquinoxalin-2-one

: 313368-82-0
4-((6bR,10aS)-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)-1-(4-fluorophenyl)-1-butanone

: 1576240-17-9
C₂₃H₂₆FN₃O

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium nitrite; acetic acid / water / 1 h / 0 - 5 °C

2.1: acetic acid; zinc / 5 - 20 °C

3.1: acetic acid; hydrogenchloride / diethyl ether / 1 h / 100 °C

4.1: sodium cyanoborohydride; trifluoroacetic acid / 0.5 h / 0 - 20 °C

5.1: borane-THF / tetrahydrofuran / 1 h / Inert atmosphere; Reflux

5.2: 0.5 h / Reflux; Inert atmosphere

6.1: potassium hydroxide / butan-1-ol / 5 h / Reflux

7.1: triethylamine; potassium iodide / 1,4-dioxane; toluene / 7 h / Reflux

8.1: Chiral AD-H / ethanol; diethylamine / Resolution of racemate

With hydrogenchloride; borane-THF; sodium cyanoborohydride; acetic acid; triethylamine; trifluoroacetic acid; potassium iodide; potassium hydroxide; zinc; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; water; diethylamine; toluene; butan-1-ol; 3.1: |Fischer Indole Synthesis;
DOI:10.1021/jm401958n

Reference yield:

: 53374-52-0
1-nitroso-3-keto-1,2,3,4-tetrahydroquinoxaline

: 313368-82-0
4-((6bR,10aS)-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)-1-(4-fluorophenyl)-1-butanone

: 1576240-17-9
C₂₃H₂₆FN₃O

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic acid; zinc / 5 - 20 °C

2.1: acetic acid; hydrogenchloride / diethyl ether / 1 h / 100 °C

3.1: sodium cyanoborohydride; trifluoroacetic acid / 0.5 h / 0 - 20 °C

4.1: borane-THF / tetrahydrofuran / 1 h / Inert atmosphere; Reflux

4.2: 0.5 h / Reflux; Inert atmosphere

5.1: potassium hydroxide / butan-1-ol / 5 h / Reflux

6.1: triethylamine; potassium iodide / 1,4-dioxane; toluene / 7 h / Reflux

7.1: Chiral AD-H / ethanol; diethylamine / Resolution of racemate

With hydrogenchloride; borane-THF; sodium cyanoborohydride; acetic acid; triethylamine; trifluoroacetic acid; potassium iodide; potassium hydroxide; zinc; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; diethylamine; toluene; butan-1-ol; 2.1: |Fischer Indole Synthesis;
DOI:10.1021/jm401958n