scabellone B

Base Information

• Chemical Name: scabellone B
• CAS No.: 1338001-75-4
• Molecular Formula: C₃₄H₄₂O₆
• Molecular Weight: 546.704
• Mol file: 1338001-75-4.mol

Synonyms:

Chemical Property of scabellone B

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of scabellone B

There total 4 articles about scabellone B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-1-(3,7-dimethylocta-2,6-dien-1-yl)-2,3,5-trimethoxybenzene → scabellone B (1338001-75-4) + scabellone A

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium cerium (IV) nitrate / acetonitrile; water / 0.17 h / -40 °C

2: pyridine / dichloromethane / 48 h / 20 °C

With pyridine; ammonium cerium (IV) nitrate; In dichloromethane; water; acetonitrile;

DOI:10.1055/s-0037-1610178

Reference yield:

1,2,4-trimethoxy-benzene (135-77-3) → scabellone B (1338001-75-4) + scabellone A

Guidance literature:

Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran / 2 h / 0 °C

1.2: 1 h

2.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 2 h / -78 - 0 °C

2.2: 1 h / -78 °C

3.1: chloro-trimethyl-silane; potassium iodide / ethyl acetate / 1.5 h

4.1: ammonium cerium (IV) nitrate / acetonitrile; water / 0.17 h / -40 °C

5.1: pyridine / dichloromethane / 48 h / 20 °C

With pyridine; n-butyllithium; chloro-trimethyl-silane; ammonium cerium (IV) nitrate; N,N,N,N,-tetramethylethylenediamine; potassium iodide; In tetrahydrofuran; dichloromethane; water; ethyl acetate; acetonitrile;

DOI:10.1055/s-0037-1610178

Reference yield:

1,2,4-trimethoxy-3-(trimethylsilyl)benzene (92669-98-2) → scabellone B (1338001-75-4) + scabellone A

Guidance literature:

Multi-step reaction with 4 steps

1.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 2 h / -78 - 0 °C

1.2: 1 h / -78 °C

2.1: chloro-trimethyl-silane; potassium iodide / ethyl acetate / 1.5 h

3.1: ammonium cerium (IV) nitrate / acetonitrile; water / 0.17 h / -40 °C

4.1: pyridine / dichloromethane / 48 h / 20 °C

With pyridine; n-butyllithium; chloro-trimethyl-silane; ammonium cerium (IV) nitrate; N,N,N,N,-tetramethylethylenediamine; potassium iodide; In tetrahydrofuran; dichloromethane; water; ethyl acetate; acetonitrile;

DOI:10.1055/s-0037-1610178

upstream raw materials:

1,2,4-trimethoxy-benzene

1,2,4-trimethoxy-3-(trimethylsilyl)benzene