92669-98-2Relevant academic research and scientific papers
Metalation in hydrocarbon solvents: The mechanistic aspects of substrate-promoted ortho-metalations
Slocum,Dumbris, Seth,Brown, Scott,Jackson, Gina,LaMastus, Roslyn,Mullins, Elwood,Ray, Jonathan,Shelton, Phillip,Walstrom, Amy,Wilcox, J. Micah,Holman
, p. 8275 - 8284 (2003)
The methoxy-substituted aromatic reagents 1,2- and 1,3-dimethoxybenzene (1,2-DMB and 1,3-DMB) and 1,2,4-trimethoxybenzene (1,2,4-TMB) each undergo directed ortho-metalation in high yield in n-BuLi/hydrocarbon media without the aid of a catalyst. These rea
Biomimetic Total Synthesis of Scabellone B
Yu, Tao,Shu, Xin,Yang, Kewu,Hu, Xiangdong
supporting information, p. 1617 - 1621 (2018/06/26)
A biomimetic total synthesis of scabellone B is described. Through sequential regioselective introduction of a geranyl group by means of silyl protection, oxidative dimerization, and biomimetic oxo-6π electrocyclization with good cyclization selectivity,
Preparation method of 2-methoxy-5-geranyl p-benzoquinone derivate and Scabellone B
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Paragraph 0049-0050, (2017/09/01)
The invention discloses a preparation method of a 2-methoxy-5-geranyl p-benzoquinone derivate. The method comprises the following steps: 1, preparing an intermediate product 1,2,4-trimethoxy-3-trimethylsilyl-benzene; 2, preparing an intermediate product 1
Preparation method of 2-methoxy-5-geranyl p-benzoquinone derivate and Scabellone A
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Paragraph 0050; 0051, (2017/09/02)
The invention discloses a preparation method of a 2-methoxy-5-geranyl p-benzoquinone derivate. The method comprises the following steps: 1, preparing an intermediate product 1,2,4-trimethoxy-3-trimethylsilyl-benzene; 2, preparing an intermediate product 1
Preparation methods of 2-methoxyl-5-geranyl-p-benzoquinone derivative and Scabellone C
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Paragraph 0054; 0058; 0062; 0066; 0070; 0074; 0078, (2017/09/01)
The invention discloses a preparation method of a 2-methoxyl-5-geranyl p-benzoquinone derivative. The method is implemented by the following steps: 1, preparing a middle product 1,2,4-trimethoxy-3-trimethylsilyl-benzene; 2, preparing a middle product 1,2,
Synthesis of 1,2,4-trimethoxybenzene and its selective functionalization at C-3 by directed metalation
Alves, Ana P. L.,Junior, Jose Augusto B. C.,Slana, Glaucia B. A.,Cardoso, Jari N.,Wang, Qiang,Lopes, Rosangela S. C.,Lopes, Claudio C.
experimental part, p. 3693 - 3709 (2009/12/06)
A new and efficient strategy was developed for the preparation of 1,2,4-trimethoxybenzene (3, a powerful attractant of Euglossini bees) and its C-3 derivatives (7a-j), from vanillin (2) in 56% overall yield.
Metalation reactions. XVI. Polylithiation of 1,3,5- and 1,2,4-trimethoxybenzene
Cabiddu, Salvatore,Contini, Liliana,Fattuoni, Claudia,Floris, Costantino,Gelli, Gioanna
, p. 9279 - 9288 (2007/10/02)
Polylithiation reactions of 1,3,5- and 1,2,4-trimethoxybenzenes have been investigated. Results showed that it is possible to substitute all arylic hydrogens through one-pot sequential bimetalation/monometalation, monometalation/bimetalation or three mono
Dilithiation of Aromatic Ethers
Crowther, G. P.,Sundberg, Richard J.,Sarpeshkar, Ashok M.
, p. 4657 - 4663 (2007/10/02)
The lithiations of anisole and all the isomeric dimethoxy- and trimethoxybenzenes with 2-5 equiv of n-butyllithium/TMEDA complex have been investigated under a variety of reaction conditions.Anisole and m-dimethoxybenzene do not undergo dilithiatian, but
