2-cyano-3-(4-((5-(7-(5-(4-(bis(4-(2-ethylhexyloxy)phenyl)amino)phenyl)thiophen-2-yl)benzo[2,1,3]thiadiazol-4-yl)-thiophen-2-yl)ethynyl)phenyl)acrylic acid

Base Information

Chemical Name:2-cyano-3-(4-((5-(7-(5-(4-(bis(4-(2-ethylhexyloxy)phenyl)amino)phenyl)thiophen-2-yl)benzo[2,1,3]thiadiazol-4-yl)-thiophen-2-yl)ethynyl)phenyl)acrylic acid
CAS No.:1622445-30-0
Molecular Formula:C₆₀H₅₈N₄O₄S₃
Molecular Weight:995.343
Hs Code.:

2-cyano-3-(4-((5-(7-(5-(4-(bis(4-(2-ethylhexyloxy)phenyl)amino)phenyl)thiophen-2-yl)benzo[2,1,3]thiadiazol-4-yl)-thiophen-2-yl)ethynyl)phenyl)acrylic acid

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Chemical Property of 2-cyano-3-(4-((5-(7-(5-(4-(bis(4-(2-ethylhexyloxy)phenyl)amino)phenyl)thiophen-2-yl)benzo[2,1,3]thiadiazol-4-yl)-thiophen-2-yl)ethynyl)phenyl)acrylic acid

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Technology Process of 2-cyano-3-(4-((5-(7-(5-(4-(bis(4-(2-ethylhexyloxy)phenyl)amino)phenyl)thiophen-2-yl)benzo[2,1,3]thiadiazol-4-yl)-thiophen-2-yl)ethynyl)phenyl)acrylic acid

There total 6 articles about 2-cyano-3-(4-((5-(7-(5-(4-(bis(4-(2-ethylhexyloxy)phenyl)amino)phenyl)thiophen-2-yl)benzo[2,1,3]thiadiazol-4-yl)-thiophen-2-yl)ethynyl)phenyl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 4-((5-(7-(5-(4-(bis(4-(2-ethyl-hexyloxy)phenyl)amino)phenyl)thiophen-2-yl)benzo[2,1,3]thiadiazol-4-yl)-thiophen-2-yl)ethynyl)benzaldehyde

: 372-09-8
cyanoacetic acid

: 1622445-30-0
2-cyano-3-(4-((5-(7-(5-(4-(bis(4-(2-ethylhexyloxy)phenyl)amino)phenyl)thiophen-2-yl)benzo[2,1,3]thiadiazol-4-yl)-thiophen-2-yl)ethynyl)phenyl)acrylic acid

Guidance literature:: With ammonium acetate; acetic acid; Reflux; Inert atmosphere;
DOI:10.1002/cssc.201402164

Reference yield:

: 165190-76-1
4,7-bis(thiophen-2-yl)-2,1,3-benzothiadiazole

: 1622445-30-0
2-cyano-3-(4-((5-(7-(5-(4-(bis(4-(2-ethylhexyloxy)phenyl)amino)phenyl)thiophen-2-yl)benzo[2,1,3]thiadiazol-4-yl)-thiophen-2-yl)ethynyl)phenyl)acrylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide / 2 h / 0 - 20 °C / Inert atmosphere

2: N-iodo-succinimide; acetic acid / dichloromethane / 20 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / tetrahydrofuran; water / 24 h / Reflux; Inert atmosphere

4: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / diethylamine / Reflux; Inert atmosphere

5: potassium fluoride / dichloromethane; methanol / 0.5 h / 55 °C / Inert atmosphere

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / diethylamine / 24 h / Reflux; Inert atmosphere

7: acetic acid; ammonium acetate / Reflux; Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; potassium fluoride; N-Bromosuccinimide; N-iodo-succinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium acetate; sodium hydrogencarbonate; acetic acid; In tetrahydrofuran; methanol; dichloromethane; water; diethylamine; N,N-dimethyl-formamide; 3: |Suzuki Coupling / 4: |Sonogashira Cross-Coupling / 6: |Sonogashira Cross-Coupling / 7: |Knoevenagel Condensation;
DOI:10.1002/cssc.201402164

Reference yield:

: 4-(5-(7-(5-bromo-thiophen-2-yl)-benzo-[2,1,3]thiadiazol-4-yl)-thiophen-2-yl)-N,N-bis(4-(2-ethyl-hexyloxy)phenyl)aniline

: 1622445-30-0
2-cyano-3-(4-((5-(7-(5-(4-(bis(4-(2-ethylhexyloxy)phenyl)amino)phenyl)thiophen-2-yl)benzo[2,1,3]thiadiazol-4-yl)-thiophen-2-yl)ethynyl)phenyl)acrylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / diethylamine / Reflux; Inert atmosphere

2: potassium fluoride / dichloromethane; methanol / 0.5 h / 55 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / diethylamine / 24 h / Reflux; Inert atmosphere

4: acetic acid; ammonium acetate / Reflux; Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; potassium fluoride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium acetate; acetic acid; In methanol; dichloromethane; diethylamine; 1: |Sonogashira Cross-Coupling / 3: |Sonogashira Cross-Coupling / 4: |Knoevenagel Condensation;
DOI:10.1002/cssc.201402164