Technology Process of C22H23F4NO2
There total 7 articles about C22H23F4NO2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: nitronium tetrafluoborate / acetonitrile / 1 h / 0 °C
2: triethylamine / dichloromethane / 2 h / 0 °C
3: copper(l) iodide; dichlorobis(tri-O-tolylphosphine)palladium; triethylamine / acetonitrile / 20 °C
4: iron; acetic acid / 0.5 h / 60 °C
5: dichloromethane / 0 °C
6: potassium carbonate / dimethyl sulfoxide / 0.25 h / 140 °C / Microwave irradiation
7: chiral-OD 2 cm semi-prep column / hexane; isopropyl alcohol / Resolution of racemate
With
copper(l) iodide; nitronium tetrafluoborate; dichlorobis(tri-O-tolylphosphine)palladium; iron; potassium carbonate; acetic acid; triethylamine;
In
hexane; dichloromethane; dimethyl sulfoxide; isopropyl alcohol; acetonitrile;
3: Sonogashira coupling;
DOI:10.1016/j.bmcl.2011.09.018
- Guidance literature:
-
With
chiral-OD 2 cm semi-prep column;
In
hexane; isopropyl alcohol;
Resolution of racemate;
DOI:10.1016/j.bmcl.2011.09.018
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium carbonate / dimethyl sulfoxide / 0.25 h / 140 °C / Microwave irradiation
2: chiral-OD 2 cm semi-prep column / hexane; isopropyl alcohol / Resolution of racemate
With
potassium carbonate;
In
hexane; dimethyl sulfoxide; isopropyl alcohol;
DOI:10.1016/j.bmcl.2011.09.018
