2,4-Diamino-6-methyl-7-hydroxypteridine

Base Information

• Chemical Name: 2,4-Diamino-6-methyl-7-hydroxypteridine
• CAS No.: 19152-92-2
• Molecular Formula: C₇H₈N₆O
• Molecular Weight: 192.18
• Hs Code.: 2933990090
• NSC Number: 33414
• DSSTox Substance ID: DTXSID10172681
• ChEMBL ID: CHEMBL4759091
• Mol file: 19152-92-2.mol

Synonyms:2,4-diamino-6-methyl-7-hydroxypteridine;2,4-DMHPT

Chemical Property of 2,4-Diamino-6-methyl-7-hydroxypteridine

Chemical Property:

• Vapor Pressure: 1.79E-15mmHg at 25°C
• Boiling Point: 610°Cat760mmHg
• Flash Point: 322.7°C
• PSA: 123.57000
• Density: 1.97g/cm³
• LogP: 0.34830
• XLogP3: -1.4
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 0
• Exact Mass: 192.07595890
• Heavy Atom Count: 14
• Complexity: 290

Purity/Quality:

99%min ^*data from raw suppliers

2,4-diamino-6-methyl-7(8H)-Pteridinone 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC2=C(N=C(N=C2NC1=O)N)N

Technology Process of 2,4-Diamino-6-methyl-7-hydroxypteridine

There total 3 articles about 2,4-Diamino-6-methyl-7-hydroxypteridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

7-methoxy-6-methyl-2,4-pteridinediamine (343347-40-0) → 2,4-diamino-6-methyl-7(8H)-pteridinone (19152-92-2)

Guidance literature:

With sodium hydroxide; for 0.0833333h; Heating;

DOI:10.1002/jhet.5570240624

Reference yield:

4-Methyl-benzoic acid (3aR,4R,6R,6aR)-6-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester (98807-33-1) → 2,4-diamino-6-methyl-7(8H)-pteridinone (19152-92-2)

Guidance literature:

DOI:10.1021/ja01157a022

Reference yield:

3-amino-5-chloro-6-methyl-2-pyrazinecarbonitrile (54632-08-5) → 2,4-diamino-6-methyl-7(8H)-pteridinone (19152-92-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) CH₃ONa / 1.) methanol; 2.) reflux, 20 h.

2: 82 percent / 2percent aq. NaOH / 0.08 h / Heating

With sodium hydroxide; sodium methylate;

DOI:10.1002/jhet.5570240624

upstream raw materials:

7-methoxy-6-methyl-2,4-pteridinediamine

4-Methyl-benzoic acid (3aR,4R,6R,6aR)-6-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

3-amino-5-chloro-6-methyl-2-pyrazinecarbonitrile

Downstream raw materials:

6-methylisoxanthopterin

Refernces

• 1、 Neilsen,Broadbent,Hennen. "Unequivocal syntheses of 6-methyl- and 6-phenylisoxanthopterin". . p. 1621 - 1628. Retrieved 2007/10/02.