5-Methylimidazo[1,2-a]pyridine-2-carboxylic acid

Base Information

• Chemical Name: 5-Methylimidazo[1,2-a]pyridine-2-carboxylic acid
• CAS No.: 88751-06-8
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.175
• Hs Code.: 2933990090
• European Community (EC) Number: 851-372-3
• DSSTox Substance ID: DTXSID50366209
• Wikidata: Q82151332
• ChEMBL ID: CHEMBL4128681
• Mol file: 88751-06-8.mol

Synonyms:5-methylimidazo[1,2-a]pyridine-2-carboxylic acid;88751-06-8;5-Methyl-imidazo[1,2-a]pyridine-2-carboxylic acid;MFCD03419472;5-Methylimidazo[1,2-a]pyridine-2-carboxylicacid;SCHEMBL119926;CHEMBL4128681;DTXSID50366209;ITABKLPNHAGZEG-UHFFFAOYSA-N;BBL021368;STK894080;AKOS000506088;AB14494;CS-W022415;DS-0128;FS-2926;AM20061593;BB 0221331;FT-0694773;EN300-34226;J-517811;5-METHYL-IMIDAZ[1,2-A]PYRIDINE-2-CARBOXYLIC ACID;5-Methyl-imidazo[1,2-a]pyridine-2-carboxylic acid, AldrichCPR

Chemical Property of 5-Methylimidazo[1,2-a]pyridine-2-carboxylic acid

Chemical Property:

• Melting Point: 247-249 °C(Solv: methanol (67-56-1))
• Refractive Index: 1.653
• PKA: -4.31±0.41(Predicted)
• PSA: 54.60000
• Density: 1.35 g/cm³
• LogP: 1.34090
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 176.058577502
• Heavy Atom Count: 13
• Complexity: 220

Purity/Quality:

99%, ^*data from raw suppliers

5-Methyl-Imidazo[1,2-a]pyridine-2-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=CC2=NC(=CN12)C(=O)O
• Uses: 5-Methylimidazo[1,2-a]pyridine-2-carboxylic acid

Technology Process of 5-Methylimidazo[1,2-a]pyridine-2-carboxylic acid

There total 3 articles about 5-Methylimidazo[1,2-a]pyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

ethyl 5-methylimidazo<1,2-a>pyridine-2-carboxylate (67625-35-8) → 5-Methyl-imidazo[1,2-a]pyridine-2-carboxylic acid (88751-06-8)

Guidance literature:

With sodium hydroxide; In ethanol; water; for 1h; Heating;

Reference yield:

5-methyl-1,8a-dihydro-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester → 5-Methyl-imidazo[1,2-a]pyridine-2-carboxylic acid (88751-06-8)

Guidance literature:

In 6-fluoroimidazo[1,2-a]pyridine-2-carboxylic acid;

Reference yield:

2-Amino-6-methylpyridine (1824-81-3) → 5-Methyl-imidazo[1,2-a]pyridine-2-carboxylic acid (88751-06-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / ethanol / 5 h / Heating

2: 65 percent / 1 N NaOH / ethanol; H₂O / 1 h / Heating

With sodium hydroxide; In ethanol; water;

upstream raw materials:

ethyl 5-methylimidazo<1,2-a>pyridine-2-carboxylate

2-Amino-6-methylpyridine

Downstream raw materials:

N-((1s,4s)-4-(5-fluoro-2-(3-iodophenoxy)nicotinamido)cyclohexyl)-5-methylimidazo[1,2-a]pyridine-2-carboxamide

N-((1s,4s)-4-(2-(2'-((dimethylamino)methyl)-4'-hydroxybiphenyl-3-yloxy)-5-fluoronicotinamido)cyclohexyl)-5-methylimidazo[1,2-a]pyridine-2-carboxamide trifluoroacetic acid salt

N-((1s,4s)-4-(2-(2'-((1,4-oxazepan-4-yl)methyl)-4'-hydroxybiphenyl-3-yloxy)-5-fluoronicotinamido)cyclohexyl)-5-methylimidazo[1,2-a]pyridine-2-carboxamide trifluoroacetic acid salt

N-((1s,4s)-4-(5-fluoro-2-(4'-hydroxy-2'-(morpholinomethyl)biphenyl-3-yloxy)nicotinamido)cyclohexyl)-5-methylimidazo[1,2-a]pyridine-2-carboxamide trifluoroacetic acid salt

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