Pyrazolo[1,5-a]pyridin-4-ol

Base Information

• Chemical Name: Pyrazolo[1,5-a]pyridin-4-ol
• CAS No.: 141032-72-6
• Molecular Formula: C7H6N2O
• Molecular Weight: 134.137
• European Community (EC) Number: 827-352-5
• DSSTox Substance ID: DTXSID90570580
• Nikkaji Number: J765.233J
• Wikidata: Q82458081
• Mol file: 141032-72-6.mol

Synonyms:Pyrazolo[1,5-a]pyridin-4-ol;141032-72-6;SCHEMBL2959947;DTXSID90570580;UYVZRUORQWAFPS-UHFFFAOYSA-N;4-hydroxypyrazolo[1,5-a]pyridine;AMY30471;MFCD00909429;AKOS006273712;BS-49772;CS-0187619;EN300-1165087;Z1198155673

Chemical Property of Pyrazolo[1,5-a]pyridin-4-ol

Chemical Property:

• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 134.048012819
• Heavy Atom Count: 10
• Complexity: 129

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN2C(=CC=N2)C(=C1)O

Technology Process of Pyrazolo[1,5-a]pyridin-4-ol

There total 11 articles about Pyrazolo[1,5-a]pyridin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

methyl 4-methoxypyrazolo[1,5-a]pyridine-3-carboxylate (1060724-61-9) → 4-hydroxypyrazolo[1,5-a]pyridine (141032-72-6)

Guidance literature:

With hydrogen bromide; for 16h; Reflux;

DOI:10.1021/jm5004039

Reference yield: 72.0%

→ 4-hydroxypyrazolo[1,5-a]pyridine (141032-72-6)

Guidance literature:

Reference yield: 53.0%

ethyl 4-methoxypyrazolo[1,5-a]pyridine-3-carboxylate (909717-95-9) → 4-hydroxypyrazolo[1,5-a]pyridine (141032-72-6)

Guidance literature:

With hydrogen bromide; at 100 ℃; for 48h;

upstream raw materials:

methyl 4-benzyloxy-pyrazolo[1,5-a]-pyridine-3-carboxylate

3-HYDROXYPYRIDINE

3-benzyloxypyridine

ethyl 4-methoxypyrazolo[1,5-a]pyridine-3-carboxylate

Downstream raw materials:

4-(2-chloro-4-nitrophenoxy)pyrazolo[1,5-a]pyridine

1-(pyrazolo[1,5-a]pyridin-4-yl)ethanone

4-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine

4-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}pyrazolo[1,5-a]pyridine-3-carbaldehyde