1-(3-Methoxyphenyl)-2-(4-methylbenzene-1-sulfonyl)propan-1-one

Base Information

Chemical Name:1-(3-Methoxyphenyl)-2-(4-methylbenzene-1-sulfonyl)propan-1-one
CAS No.:141036-69-3
Molecular Formula:C₁₇H₁₈O₄S
Molecular Weight:318.394
Hs Code.:
DSSTox Substance ID:DTXSID90577610

Synonyms:141036-69-3;DTXSID90577610;1-(3-Methoxyphenyl)-2-(4-methylbenzene-1-sulfonyl)propan-1-one

Suppliers and Price of 1-(3-Methoxyphenyl)-2-(4-methylbenzene-1-sulfonyl)propan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(3-Methoxyphenyl)-2-(4-methylbenzene-1-sulfonyl)propan-1-one

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:318.09258022
Heavy Atom Count:22
Complexity:471

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)C(C)C(=O)C2=CC(=CC=C2)OC

Technology Process of 1-(3-Methoxyphenyl)-2-(4-methylbenzene-1-sulfonyl)propan-1-one

There total 8 articles about 1-(3-Methoxyphenyl)-2-(4-methylbenzene-1-sulfonyl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 75-07-0,9002-91-9
acetaldehyde

: Lithium; (E)-1-(3-methoxy-phenyl)-2-(toluene-4-sulfonyl)-propen-1-olate

: 141036-69-3
1-(3-methoxyphenyl)-2-(p-tolylsulfonyl)-1-propanone

: 141036-78-4
3-Hydroxy-1-(3-methoxy-phenyl)-2-methyl-2-(toluene-4-sulfonyl)-butan-1-one

Guidance literature:: DOI:10.1246/cl.1992.381

Reference yield: 53.0%

: 541-41-3
chloroformic acid ethyl ester

: Lithium; (E)-1-(3-methoxy-phenyl)-2-(toluene-4-sulfonyl)-propen-1-olate

: 141036-69-3
1-(3-methoxyphenyl)-2-(p-tolylsulfonyl)-1-propanone

: 141036-77-3
Carbonic acid ethyl ester (Z)-1-(3-methoxy-phenyl)-2-(toluene-4-sulfonyl)-propenyl ester

Guidance literature:: DOI:10.1246/cl.1992.381

Reference yield:

: 50635-71-7,50635-72-8,31350-93-3
1-chloroethyl p-tolyl sulfoxide

: 141036-69-3
1-(3-methoxyphenyl)-2-(p-tolylsulfonyl)-1-propanone

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) LDA / 1.) THF, -60 deg C, 2.) THF

2: 97 percent / 3-chloroperoxybenzoic acid / CH₂Cl₂ / Ambient temperature

3: 100 percent / Swern oxidation reagent

4: 1.) n-BuLi, 2.) Et₃N / 1.) THF, -60 deg C

5: H₂O, silica gel

With n-butyllithium; Swern oxidation reagent; water; silica gel; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In dichloromethane;
DOI:10.1246/cl.1992.381