D-Phenylalaninamide, N-[(phenylmethoxy)carbonyl]-L-phenylalanyl-

Base Information

• Chemical Name: D-Phenylalaninamide, N-[(phenylmethoxy)carbonyl]-L-phenylalanyl-
• CAS No.: 141056-54-4
• Molecular Formula: C₂₆H₂₇N₃O₄
• Molecular Weight: 445.518
• Mol file: 141056-54-4.mol

Synonyms:Z-L-Phe-L-Phe-NH2;N-benzyloxycarbonyl-L-phenylalanyl-L-phenylalaninamide;Cbz-Phe-Phe-NH2;Z-Phe-Phe-NH2;Z-Phe-Phe-CONH2;N-(N-benzyloxycarbonyl-L-phenylalanyl)-L-phenylalanine amide;

Chemical Property of D-Phenylalaninamide, N-[(phenylmethoxy)carbonyl]-L-phenylalanyl-

Chemical Property:

• PSA: 110.52000
• LogP: 4.21900

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of D-Phenylalaninamide, N-[(phenylmethoxy)carbonyl]-L-phenylalanyl-

There total 32 articles about D-Phenylalaninamide, N-[(phenylmethoxy)carbonyl]-L-phenylalanyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

L-Phenylalanine amide (5241-58-7) + N-Cbz-L-Phe (1161-13-3) → N-benzyloxycarbonyl-L-phenylalanyl-L-phenylalaninamide (141056-54-4,141056-55-5,17187-06-3)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.5012/bkcs.2010.31.04.874

Reference yield: 94.0%

L-Phenylalanine amide (5241-58-7) + N-(benzyloxycarbonyl)-L-phenylalanine benzyl ester (60379-01-3) → N-benzyloxycarbonyl-L-phenylalanyl-L-phenylalaninamide (141056-54-4,141056-55-5,17187-06-3)

Guidance literature:

With subtilisin-CLEC; In acetonitrile; at 40 ℃; for 23h;

DOI:10.1021/jo9618334

Reference yield: 87.4%

L-Phenylalanine amide (5241-58-7) + N-(carbobenzyloxy)phenylalanine cyanomethyl ester (7663-85-6) → N-Cbz-L-Phe (1161-13-3) + N-benzyloxycarbonyl-L-phenylalanyl-L-phenylalaninamide (141056-54-4,141056-55-5,17187-06-3)

Guidance literature:

With phosphate buffer; α-chymotrypsin; In dimethyl sulfoxide; at -24 ℃; for 0.5h; pH=8.0;

DOI:10.1016/j.tetasy.2005.10.042

upstream raw materials:

Z-L-Phe-L-Phe-OEt

N-Cbz-L-Phe

benzoyl chloride

L-Phenylalanine amide

Downstream raw materials:

di(phenylalanine)

N-benzyloxycarbonyl-L-phenylalanyl-gem-L-phenylalanine hydrochloride