2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID HYDRAZIDE

Base Information

• Chemical Name: 2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID HYDRAZIDE
• CAS No.: 4779-54-8
• Molecular Formula: C16H13N3O
• Molecular Weight: 263.299
• Hs Code.: 2933499090
• Mol file: 4779-54-8.mol

Synonyms:Cinchoninicacid, 2-phenyl-, hydrazide (7CI,8CI);2-Phenylcinchoninic acid hydrazide;2-Phenylquinoline-4-carboxylic acid hydrazide;Cinchophen hydrazide;NSC 13140;NSC 19426;

Chemical Property of 2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID HYDRAZIDE

Chemical Property:

• Refractive Index: 1.681
• PSA: 68.01000
• Density: 1.256 g/cm³
• LogP: 3.59650

Purity/Quality:

97% ^*data from raw suppliers

2-Phenylquinoline-4-carbohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID HYDRAZIDE

There total 8 articles about 2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID HYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethyl 2-phenylquinoline-4-carboxylate (4420-46-6) → 2-phenylquinoline-4-carboxylic acid hydrazide (4779-54-8)

Guidance literature:

With hydrazine hydrate; at 50 - 60 ℃;

DOI:10.1080/14756366.2016.1190714

Reference yield: 86.0%

methyl 2-phenylquinoline-4-carboxylate (4546-48-9) → 2-phenylquinoline-4-carboxylic acid hydrazide (4779-54-8)

Guidance literature:

With hydrazine hydrochloride; sodium hydroxide; In ethanol; for 20h; Reflux;

DOI:10.1016/j.jfluchem.2016.08.012

Reference yield:

cinchophen (132-60-5) → 2-phenylquinoline-4-carboxylic acid hydrazide (4779-54-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid

2: hydrazine hydrate

With sulfuric acid; hydrazine hydrate;

DOI:10.1002/jccs.200400049

upstream raw materials:

ethyl 2-phenylquinoline-4-carboxylate

cinchophen

acetophenone

methyl 2-phenylquinoline-4-carboxylate

Downstream raw materials:

NCI-130847

2-phenyl-quinoline-4-carboxylic acid-(3-nitro-benzylidenehydrazide)

2-phenyl-quinoline-4-carboxylic acid-{4-[bis-(2-chloro-ethyl)-amino]-benzylidenehydrazide}

2-Phenyl-quinoline-4-carboxylic acid [1-[5-(2-hydroxy-adamantan-2-yl)-thiophen-2-yl]-meth-(E)-ylidene]-hydrazide