[5-(tert-butyl-dimethyl-silanyloxy)-2-cyclopentyl-4-(4-fluoro-phenyl)-7,7-dimethyl-5,6,7,8-tetrahydro-quinolin-3-yl]-(4-trifluoromethyl-phenyl)-methanone

Base Information

Chemical Name:[5-(tert-butyl-dimethyl-silanyloxy)-2-cyclopentyl-4-(4-fluoro-phenyl)-7,7-dimethyl-5,6,7,8-tetrahydro-quinolin-3-yl]-(4-trifluoromethyl-phenyl)-methanone
CAS No.:202263-74-9
Molecular Formula:C₃₆H₄₃F₄NO₂Si
Molecular Weight:625.822
Hs Code.:

[5-(<i>tert</i>-butyl-dimethyl-silanyloxy)-2-cyclopentyl-4-(4-fluoro-phenyl)-7,7-dimethyl-5,6,7,8-tetrahydro-quinolin-3-yl]-(4-trifluoromethyl-phenyl)-methanone

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Chemical Property of [5-(tert-butyl-dimethyl-silanyloxy)-2-cyclopentyl-4-(4-fluoro-phenyl)-7,7-dimethyl-5,6,7,8-tetrahydro-quinolin-3-yl]-(4-trifluoromethyl-phenyl)-methanone

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Technology Process of [5-(tert-butyl-dimethyl-silanyloxy)-2-cyclopentyl-4-(4-fluoro-phenyl)-7,7-dimethyl-5,6,7,8-tetrahydro-quinolin-3-yl]-(4-trifluoromethyl-phenyl)-methanone

There total 5 articles about [5-(tert-butyl-dimethyl-silanyloxy)-2-cyclopentyl-4-(4-fluoro-phenyl)-7,7-dimethyl-5,6,7,8-tetrahydro-quinolin-3-yl]-(4-trifluoromethyl-phenyl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 709-63-7
1-(4-trifluoromethylphenyl)ethanone

: 202263-74-9
[5-(tert-butyl-dimethyl-silanyloxy)-2-cyclopentyl-4-(4-fluoro-phenyl)-7,7-dimethyl-5,6,7,8-tetrahydro-quinolin-3-yl]-(4-trifluoromethyl-phenyl)-methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH; 18-crown-6

1.2: NH₄QAc

2.1: 45 percent / TFA

3.1: 86 percent / MnO₂

4.1: BH₃*Et₂NPh; (1R,2S)-1-aminoindanol

With manganese(IV) oxide; borane N,N-diethylaniline complex; 18-crown-6 ether; (1R,2S)-1-Amino-2-indanol; sodium hydride; trifluoroacetic acid;
DOI:10.2533/000942904777678082

Reference yield:

: 3-Amino-3-cyclopentyl-1-(4-trifluoromethylphenyl)-propenone

: 202263-74-9
[5-(tert-butyl-dimethyl-silanyloxy)-2-cyclopentyl-4-(4-fluoro-phenyl)-7,7-dimethyl-5,6,7,8-tetrahydro-quinolin-3-yl]-(4-trifluoromethyl-phenyl)-methanone

Guidance literature:: Multi-step reaction with 4 steps

1: 45 percent / TFA

2: 86 percent / MnO₂

3: BH₃*Et₂NPh; (1R,2S)-1-aminoindanol

With manganese(IV) oxide; borane N,N-diethylaniline complex; (1R,2S)-1-Amino-2-indanol; trifluoroacetic acid;
DOI:10.2533/000942904777678082

Reference yield:

: 202263-68-1
2-cyclopentyl-4-(4-fluorophenyl)-7,7-dimethyl-3-(4-trifluoromethylbenzoyl)-7,8-dihydro-6H-quinolin-5-one

: 202263-74-9
[5-(tert-butyl-dimethyl-silanyloxy)-2-cyclopentyl-4-(4-fluoro-phenyl)-7,7-dimethyl-5,6,7,8-tetrahydro-quinolin-3-yl]-(4-trifluoromethyl-phenyl)-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: BH₃*Et₂NPh; (1R,2S)-1-aminoindanol

With borane N,N-diethylaniline complex; (1R,2S)-1-Amino-2-indanol;
DOI:10.2533/000942904777678082