(S)-4-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-4-((S)-2-methyl-1-{(S)-2-[N'-(2,2,2-trichloro-ethoxycarbonyl)-hydrazinocarbonyl]-pyrrolidine-1-carbonyl}-propylcarbamoyl)-butyric acid benzyl ester

Base Information

• Chemical Name: (S)-4-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-4-((S)-2-methyl-1-{(S)-2-[N'-(2,2,2-trichloro-ethoxycarbonyl)-hydrazinocarbonyl]-pyrrolidine-1-carbonyl}-propylcarbamoyl)-butyric acid benzyl ester
• CAS No.: 119155-29-2
• Molecular Formula: C₄₄H₆₀Cl₃N₇O₁₂
• Molecular Weight: 985.359

Synonyms:

Chemical Property of (S)-4-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-4-((S)-2-methyl-1-{(S)-2-[N'-(2,2,2-trichloro-ethoxycarbonyl)-hydrazinocarbonyl]-pyrrolidine-1-carbonyl}-propylcarbamoyl)-butyric acid benzyl ester

Chemical Property:

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Useful:

Technology Process of (S)-4-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-4-((S)-2-methyl-1-{(S)-2-[N'-(2,2,2-trichloro-ethoxycarbonyl)-hydrazinocarbonyl]-pyrrolidine-1-carbonyl}-propylcarbamoyl)-butyric acid benzyl ester

There total 4 articles about (S)-4-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-4-((S)-2-methyl-1-{(S)-2-[N'-(2,2,2-trichloro-ethoxycarbonyl)-hydrazinocarbonyl]-pyrrolidine-1-carbonyl}-propylcarbamoyl)-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Boc-Val-ONSu (3392-12-9) → (S)-4-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-4-((S)-2-methyl-1-{(S)-2-[N'-(2,2,2-trichloro-ethoxycarbonyl)-hydrazinocarbonyl]-pyrrolidine-1-carbonyl}-propylcarbamoyl)-butyric acid benzyl ester (119155-29-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) TFA, anisole; 2.) N-methylmorpholine / 1.) 40 min; 2.) DMF, room temperature, 5 h

2: 1.) TFA, anisole; 2.) N-methylmorpholine / 1.) 40 min; 2.) DMF, room temperature, 5 h

3: 1.) TFA, anisole; 2.) N-methylmorpholine / 1.) 40 min; 2.) DMF, room temperature, 5 h

With 4-methyl-morpholine; methoxybenzene; trifluoroacetic acid;

DOI:10.1248/cpb.36.2506

Reference yield:

Boc-Pro-NHNH-Troc (87329-18-8) → (S)-4-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-4-((S)-2-methyl-1-{(S)-2-[N'-(2,2,2-trichloro-ethoxycarbonyl)-hydrazinocarbonyl]-pyrrolidine-1-carbonyl}-propylcarbamoyl)-butyric acid benzyl ester (119155-29-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) TFA, anisole; 2.) N-methylmorpholine / 1.) 40 min; 2.) DMF, room temperature, 5 h

2: 1.) TFA, anisole; 2.) N-methylmorpholine / 1.) 40 min; 2.) DMF, room temperature, 5 h

3: 1.) TFA, anisole; 2.) N-methylmorpholine / 1.) 40 min; 2.) DMF, room temperature, 5 h

With 4-methyl-morpholine; methoxybenzene; trifluoroacetic acid;

DOI:10.1248/cpb.36.2506

Reference yield:

N'-[(S)-1-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-hydrazinecarboxylic acid 2,2,2-trichloro-ethyl ester (119155-27-0) → (S)-4-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-4-((S)-2-methyl-1-{(S)-2-[N'-(2,2,2-trichloro-ethoxycarbonyl)-hydrazinocarbonyl]-pyrrolidine-1-carbonyl}-propylcarbamoyl)-butyric acid benzyl ester (119155-29-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) TFA, anisole; 2.) N-methylmorpholine / 1.) 40 min; 2.) DMF, room temperature, 5 h

2: 1.) TFA, anisole; 2.) N-methylmorpholine / 1.) 40 min; 2.) DMF, room temperature, 5 h

With 4-methyl-morpholine; methoxybenzene; trifluoroacetic acid;

DOI:10.1248/cpb.36.2506

upstream raw materials:

Boc-Lys(Z)-OSu

(S)-4-tert-Butoxycarbonylamino-4-((S)-2-methyl-1-{(S)-2-[N'-(2,2,2-trichloro-ethoxycarbonyl)-hydrazinocarbonyl]-pyrrolidine-1-carbonyl}-propylcarbamoyl)-butyric acid benzyl ester

Boc-Val-ONSu

Boc-Pro-NHNH-Troc

Downstream raw materials:

C₄₉H₆₇Cl₃N₈O₁₃

C₅₅H₇₈Cl₃N₉O₁₄

C₅₄H₈₀N₁₀O₁₃

C₅₇H₈₁Cl₃N₁₀O₁₅

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