(S)-2-benzyloxycarbonylamino-4-(toluene-4-sulfonylamino)-butyryl=>-L_S-threonyl=>(S)-2-amino-4-(toluene-4-sulfonylamino)-butyryl=>L_S-threonine ethyl ester

Base Information

• Chemical Name: (S)-2-benzyloxycarbonylamino-4-(toluene-4-sulfonylamino)-butyryl=>-L_S-threonyl=>(S)-2-amino-4-(toluene-4-sulfonylamino)-butyryl=>L_S-threonine ethyl ester
• CAS No.: 121057-55-4
• Molecular Formula: C₄₀H₅₄N₆O₁₃S₂
• Molecular Weight: 891.033
• Mol file: 121057-55-4.mol

Synonyms:

Chemical Property of (S)-2-benzyloxycarbonylamino-4-(toluene-4-sulfonylamino)-butyryl=>-L_S-threonyl=>(S)-2-amino-4-(toluene-4-sulfonylamino)-butyryl=>L_S-threonine ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-benzyloxycarbonylamino-4-(toluene-4-sulfonylamino)-butyryl=>-L_S-threonyl=>(S)-2-amino-4-(toluene-4-sulfonylamino)-butyryl=>L_S-threonine ethyl ester

There total 10 articles about (S)-2-benzyloxycarbonylamino-4-(toluene-4-sulfonylamino)-butyryl=>-L_S-threonyl=>(S)-2-amino-4-(toluene-4-sulfonylamino)-butyryl=>L_S-threonine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[(S)-2-benzyloxycarbonylamino-4-(toluene-4-sulfonylamino)-butyryl]-LS-threonine (121599-55-1) → (S)-2-benzyloxycarbonylamino-4-(toluene-4-sulfonylamino)-butyryl=>-LS-threonyl=>(S)-2-amino-4-(toluene-4-sulfonylamino)-butyryl=>LS-threonine ethyl ester (121057-55-4)

Guidance literature:

With dicyclohexyl-carbodiimide;

Reference yield:

(S)-2,4-bis-(toluene-4-sulfonylamino)-butyric acid (25139-85-9) → (S)-2-benzyloxycarbonylamino-4-(toluene-4-sulfonylamino)-butyryl=>-LS-threonyl=>(S)-2-amino-4-(toluene-4-sulfonylamino)-butyryl=>LS-threonine ethyl ester (121057-55-4)

Guidance literature:

Multi-step reaction with 8 steps

1: aqueous HBr; acetic acid; phenol

2: aqueous NaOH

5: water; methanol; dioxane; N₂H₄

6: NaNO₂; aqueous HCl; acetic acid / und anschliessend mit L_S-Threonin-aethylester in Aether,Dioxan und Essigsaeure

7: aqueous NaOH

8: dicyclohexylcarbodiimide

With 1,4-dioxane; hydrogenchloride; methanol; sodium hydroxide; water; hydrogen bromide; acetic acid; dicyclohexyl-carbodiimide; hydrazine; sodium nitrite; phenol;

Reference yield:

N2-p-toluenesulfonyl-L-2,4-diaminobutyric acid (62234-29-1) → (S)-2-benzyloxycarbonylamino-4-(toluene-4-sulfonylamino)-butyryl=>-LS-threonyl=>(S)-2-amino-4-(toluene-4-sulfonylamino)-butyryl=>LS-threonine ethyl ester (121057-55-4)

Guidance literature:

Multi-step reaction with 9 steps

1: TsCl

2: aqueous HBr; acetic acid; phenol

3: aqueous NaOH

6: water; methanol; dioxane; N₂H₄

7: NaNO₂; aqueous HCl; acetic acid / und anschliessend mit L_S-Threonin-aethylester in Aether,Dioxan und Essigsaeure

8: aqueous NaOH

9: dicyclohexylcarbodiimide

With 1,4-dioxane; hydrogenchloride; methanol; sodium hydroxide; water; hydrogen bromide; acetic acid; p-toluenesulfonyl chloride; dicyclohexyl-carbodiimide; hydrazine; sodium nitrite; phenol;

upstream raw materials:

N-[(S)-2-benzyloxycarbonylamino-4-(toluene-4-sulfonylamino)-butyryl]-L_S-threonine

(S)-2,4-bis-(toluene-4-sulfonylamino)-butyric acid

N2-p-toluenesulfonyl-L-2,4-diaminobutyric acid

(S)-3-amino-1-(toluene-4-sulfonyl)-pyrrolidin-2-one