(R)-4-[(3aR,5R,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-1-(toluene-4-sulfonyl)-azetidin-2-one

Base Information

• Chemical Name: (R)-4-[(3aR,5R,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-1-(toluene-4-sulfonyl)-azetidin-2-one
• CAS No.: 127558-53-6
• Molecular Formula: C₂₂H₂₉NO₉S
• Molecular Weight: 483.54

Synonyms:

Chemical Property of (R)-4-[(3aR,5R,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-1-(toluene-4-sulfonyl)-azetidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-4-[(3aR,5R,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-1-(toluene-4-sulfonyl)-azetidin-2-one

There total 1 articles about (R)-4-[(3aR,5R,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-1-(toluene-4-sulfonyl)-azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2:5,6-di-O-isopropylidene-3-O-vinyl-α-D-glucofuranose (6613-69-0) + Tosyl isocyanate (4083-64-1) → (R)-4-[(3aR,5R,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-1-(toluene-4-sulfonyl)-azetidin-2-one (127558-53-6)

Guidance literature:

In diethyl ether;

DOI:10.1016/S0040-4039(01)93477-X

Reference yield:

(R)-4-[(3aR,5R,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-1-(toluene-4-sulfonyl)-azetidin-2-one (127558-53-6) → (R)-4-[(3aR,5R,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-azetidin-2-one (127558-56-9) + (S)-4-[(3aR,5R,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-azetidin-2-one (127558-65-0) + 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose (582-52-5)

Guidance literature:

With sodium; In ammonia; at -50 ℃; Yield given;

DOI:10.1016/S0040-4039(01)93477-X

upstream raw materials:

1,2:5,6-di-O-isopropylidene-3-O-vinyl-α-D-glucofuranose

Tosyl isocyanate

Downstream raw materials:

(R)-4-[(3aR,5R,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-azetidin-2-one

(S)-4-[(3aR,5R,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-azetidin-2-one

1,2:5,6-di-O-isopropylidene-α-D-glucofuranose

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