2,6-Dimethyl-benzoic acid 4-{[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-diisopropylamino-phosphanyloxymethyl}-phenyl ester

Base Information

• Chemical Name: 2,6-Dimethyl-benzoic acid 4-{[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-diisopropylamino-phosphanyloxymethyl}-phenyl ester
• CAS No.: 190202-99-4
• Molecular Formula: C₅₃H₆₀N₃O₁₀P
• Molecular Weight: 930.047
• Mol file: 190202-99-4.mol

Synonyms:

Chemical Property of 2,6-Dimethyl-benzoic acid 4-{[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-diisopropylamino-phosphanyloxymethyl}-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-Dimethyl-benzoic acid 4-{[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-diisopropylamino-phosphanyloxymethyl}-phenyl ester

There total 1 articles about 2,6-Dimethyl-benzoic acid 4-{[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-diisopropylamino-phosphanyloxymethyl}-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-diisopropylphosphoramide dichloride (921-26-6) + 5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) + 2,6-Dimethyl-benzoic acid 4-hydroxymethyl-phenyl ester → 2,6-Dimethyl-benzoic acid 4-{[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-diisopropylamino-phosphanyloxymethyl}-phenyl ester (190202-99-4)

Guidance literature:

DOI:10.1016/S0960-894X(97)00119-4

Reference yield:

2,6-Dimethyl-benzoic acid 4-{[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-diisopropylamino-phosphanyloxymethyl}-phenyl ester (190202-99-4) → C36H41N4O13PS

Guidance literature:

With deprotecting; 3H-1,2-Benzodithiol-3-one 1,1-dioxide; potassium carbonate; Multistep reaction;

DOI:10.1016/S0960-894X(97)00119-4

Reference yield:

2,6-Dimethyl-benzoic acid 4-{[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-diisopropylamino-phosphanyloxymethyl}-phenyl ester (190202-99-4) → C46H53N6O20P2S(1-)

Guidance literature:

With 1H-tetrazole; tert.-butylhydroperoxide; potassium carbonate; Multistep reaction;

DOI:10.1016/S0960-894X(97)00119-4

upstream raw materials:

N,N-diisopropylphosphoramide dichloride

5'-O-(4-4'-dimethoxytrityl)thymidine