(R)-2-Benzyloxy-3-((5aR,6S,7aR,13aS,13bS)-2,2,4,4,10,10,12,12-octaisopropyl-hexahydro-1,3,5,7,9,11,13-heptaoxa-2,4,10,12-tetrasila-cyclohepta[3,4]benzo[1,2]cycloocten-6-yloxy)-propan-1-ol

Base Information

Chemical Name:(R)-2-Benzyloxy-3-((5aR,6S,7aR,13aS,13bS)-2,2,4,4,10,10,12,12-octaisopropyl-hexahydro-1,3,5,7,9,11,13-heptaoxa-2,4,10,12-tetrasila-cyclohepta[3,4]benzo[1,2]cycloocten-6-yloxy)-propan-1-ol
CAS No.:143516-80-7
Molecular Formula:C₄₀H₇₆O₁₀Si₄
Molecular Weight:829.379
Hs Code.:

(R)-2-Benzyloxy-3-((5aR,6S,7aR,13aS,13bS)-2,2,4,4,10,10,12,12-octaisopropyl-hexahydro-1,3,5,7,9,11,13-heptaoxa-2,4,10,12-tetrasila-cyclohepta[3,4]benzo[1,2]cycloocten-6-yloxy)-propan-1-ol

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Chemical Property of (R)-2-Benzyloxy-3-((5aR,6S,7aR,13aS,13bS)-2,2,4,4,10,10,12,12-octaisopropyl-hexahydro-1,3,5,7,9,11,13-heptaoxa-2,4,10,12-tetrasila-cyclohepta[3,4]benzo[1,2]cycloocten-6-yloxy)-propan-1-ol

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Technology Process of (R)-2-Benzyloxy-3-((5aR,6S,7aR,13aS,13bS)-2,2,4,4,10,10,12,12-octaisopropyl-hexahydro-1,3,5,7,9,11,13-heptaoxa-2,4,10,12-tetrasila-cyclohepta[3,4]benzo[1,2]cycloocten-6-yloxy)-propan-1-ol

There total 7 articles about (R)-2-Benzyloxy-3-((5aR,6S,7aR,13aS,13bS)-2,2,4,4,10,10,12,12-octaisopropyl-hexahydro-1,3,5,7,9,11,13-heptaoxa-2,4,10,12-tetrasila-cyclohepta[3,4]benzo[1,2]cycloocten-6-yloxy)-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 143516-76-1
(5aR,6S,7aR,13aS,13bS)-6-((E)-(R)-2-Benzyloxy-pent-3-enyloxy)-2,2,4,4,10,10,12,12-octaisopropyl-hexahydro-1,3,5,7,9,11,13-heptaoxa-2,4,10,12-tetrasila-cyclohepta[3,4]benzo[1,2]cyclooctene

: 143516-80-7
(R)-2-Benzyloxy-3-((5aR,6S,7aR,13aS,13bS)-2,2,4,4,10,10,12,12-octaisopropyl-hexahydro-1,3,5,7,9,11,13-heptaoxa-2,4,10,12-tetrasila-cyclohepta[3,4]benzo[1,2]cycloocten-6-yloxy)-propan-1-ol

Guidance literature:: With sodium tetrahydroborate; ozone; Yield given. Multistep reaction; 1.) EtOH, - 78 deg C, 30 min, 2.) RT, 30 min;
DOI:10.1248/cpb.40.1166

Reference yield:

: 69304-37-6
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

: 143516-80-7
(R)-2-Benzyloxy-3-((5aR,6S,7aR,13aS,13bS)-2,2,4,4,10,10,12,12-octaisopropyl-hexahydro-1,3,5,7,9,11,13-heptaoxa-2,4,10,12-tetrasila-cyclohepta[3,4]benzo[1,2]cycloocten-6-yloxy)-propan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 107 mg / pyridine / 0.17 h / Ambient temperature

2: 1.) O₃, 2.) NaBH₄ / 1.) EtOH, - 78 deg C, 30 min, 2.) RT, 30 min

With pyridine; sodium tetrahydroborate; ozone;
DOI:10.1248/cpb.40.1166

Reference yield:

: 100-39-0
benzyl bromide

: 143516-80-7
(R)-2-Benzyloxy-3-((5aR,6S,7aR,13aS,13bS)-2,2,4,4,10,10,12,12-octaisopropyl-hexahydro-1,3,5,7,9,11,13-heptaoxa-2,4,10,12-tetrasila-cyclohepta[3,4]benzo[1,2]cycloocten-6-yloxy)-propan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) Na / 1.) liq. NH₃, - 78 deg C, 10 min, 2.) liq. NH₃, - 78 deg C, 20 min

2: 304 mg / 9 percent HCl-MeOH / 2 h / Ambient temperature

3: 1.) molecular sieves 4A, 2.) BF₃-Et₂O / 1.) CH₂Cl₂, - 30 deg C, 10 min, 2.) - 30 deg C, 40 min

4: 60 mg / 10 percent KOH-MeOH / 1 h / 0 °C

5: 107 mg / pyridine / 0.17 h / Ambient temperature

6: 1.) O₃, 2.) NaBH₄ / 1.) EtOH, - 78 deg C, 30 min, 2.) RT, 30 min

With pyridine; hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; 4 A molecular sieve; boron trifluoride diethyl etherate; sodium; ozone;
DOI:10.1248/cpb.40.1166