Cyclohexanecarboxylic acid, 2-ethenyl-5-[1-hydroxy-1-methyl-2-(phenylsulfonyl)-3-(2,2,5,5-tetramethyl -1,3-dioxolan-4-yl)propyl]-2-methyl-, methyl ester

Base Information

Chemical Name:Cyclohexanecarboxylic acid, 2-ethenyl-5-[1-hydroxy-1-methyl-2-(phenylsulfonyl)-3-(2,2,5,5-tetramethyl -1,3-dioxolan-4-yl)propyl]-2-methyl-, methyl ester
CAS No.:141210-98-2
Molecular Formula:C₂₈H₄₂O₇S
Molecular Weight:522.703
Hs Code.:
Mol file:141210-98-2.mol

Cyclohexanecarboxylic acid,
2-ethenyl-5-[1-hydroxy-1-methyl-2-(phenylsulfonyl)-3-(2,2,5,5-tetramethyl
-1,3-dioxolan-4-yl)propyl]-2-methyl-, methyl ester

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclohexanecarboxylic acid, 2-ethenyl-5-[1-hydroxy-1-methyl-2-(phenylsulfonyl)-3-(2,2,5,5-tetramethyl -1,3-dioxolan-4-yl)propyl]-2-methyl-, methyl ester

Chemical Property:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of Cyclohexanecarboxylic acid, 2-ethenyl-5-[1-hydroxy-1-methyl-2-(phenylsulfonyl)-3-(2,2,5,5-tetramethyl -1,3-dioxolan-4-yl)propyl]-2-methyl-, methyl ester

There total 6 articles about Cyclohexanecarboxylic acid, 2-ethenyl-5-[1-hydroxy-1-methyl-2-(phenylsulfonyl)-3-(2,2,5,5-tetramethyl -1,3-dioxolan-4-yl)propyl]-2-methyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3112-85-4
methylphenylsulfonate

: 141210-98-2
(1S,2R,5S)-5-[2-Benzenesulfonyl-1-hydroxy-1-methyl-3-((R)-2,2,5,5-tetramethyl-[1,3]dioxolan-4-yl)-propyl]-2-methyl-2-vinyl-cyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) BuLi / 1.) THF, HMPA, -20 deg C to 25 deg C

2: 1.) BuLi, 2.) BF₃*OEt₂ / 2.) THF, -78 deg C , 20 min

With n-butyllithium; boron trifluoride diethyl etherate;
DOI:10.1248/cpb.40.556

Reference yield:

: 139694-40-9
(1S,2S,5R,6R)-5-Acetyl-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-formyl-2-methyl-cyclohexanecarboxylic acid methyl ester

: 141210-98-2
(1S,2R,5S)-5-[2-Benzenesulfonyl-1-hydroxy-1-methyl-3-((R)-2,2,5,5-tetramethyl-[1,3]dioxolan-4-yl)-propyl]-2-methyl-2-vinyl-cyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 79 percent / Zn, Me₃Al

2: 83 percent / MeONa

3: 1.) 80percent AcOH, 2.) NaIO₄, 3.) NaClO₂, 4.) (COCl)2, pyridine, 5.) N-hydroxypyridine-2-thione sodium salt, DMAP, 6.) Bu₃SnH, AIBN

4: 1.) BuLi, 2.) BF₃*OEt₂ / 2.) THF, -78 deg C , 20 min

With pyridine; dmap; sodium chlorite; sodium periodate; n-butyllithium; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); boron trifluoride diethyl etherate; trimethylaluminum; tri-n-butyl-tin hydride; sodium methylate; 2-mercaptopyridine-1-oxide sodium salt; acetic acid; zinc;
DOI:10.1248/cpb.40.556

Reference yield:

: 141210-95-9
(1S,2R,5R,6R)-5-Acetyl-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-2-vinyl-cyclohexanecarboxylic acid methyl ester

: 141210-98-2
(1S,2R,5S)-5-[2-Benzenesulfonyl-1-hydroxy-1-methyl-3-((R)-2,2,5,5-tetramethyl-[1,3]dioxolan-4-yl)-propyl]-2-methyl-2-vinyl-cyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / MeONa

2: 1.) 80percent AcOH, 2.) NaIO₄, 3.) NaClO₂, 4.) (COCl)2, pyridine, 5.) N-hydroxypyridine-2-thione sodium salt, DMAP, 6.) Bu₃SnH, AIBN

3: 1.) BuLi, 2.) BF₃*OEt₂ / 2.) THF, -78 deg C , 20 min

With pyridine; dmap; sodium chlorite; sodium periodate; n-butyllithium; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); boron trifluoride diethyl etherate; tri-n-butyl-tin hydride; sodium methylate; 2-mercaptopyridine-1-oxide sodium salt; acetic acid;
DOI:10.1248/cpb.40.556