2-[(2R,3R)-2-Acetylsulfanyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-2-enoic acid 2,2,2-trichloro-ethyl ester

Base Information

• Chemical Name: 2-[(2R,3R)-2-Acetylsulfanyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-2-enoic acid 2,2,2-trichloro-ethyl ester
• CAS No.: 30825-22-0
• Molecular Formula: C₂₀H₂₁Cl₃N₂O₆S
• Molecular Weight: 523.822
• Mol file: 30825-22-0.mol

Synonyms:

Chemical Property of 2-[(2R,3R)-2-Acetylsulfanyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-2-enoic acid 2,2,2-trichloro-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(2R,3R)-2-Acetylsulfanyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-2-enoic acid 2,2,2-trichloro-ethyl ester

There total 3 articles about 2-[(2R,3R)-2-Acetylsulfanyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-2-enoic acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6β-(2-phenoxy-acetylamino)-penicillanic acid 2,2,2-trichloro-ethyl ester (19474-19-2) + acetyl chloride (75-36-5) → 2-[(2R,3R)-2-Acetylsulfanyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-2-enoic acid 2,2,2-trichloro-ethyl ester (30825-22-0)

Guidance literature:

With DBN; phenylmercury(II) chloride; Yield given. Multistep reaction; 1.) CH₃CN, RT, 0.5 h, 2.) from 15 to 20 deg C, 15 sec;

Reference yield:

→ 2-[(2R,3R)-2-Acetylsulfanyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-2-enoic acid 2,2,2-trichloro-ethyl ester (30825-22-0)

Guidance literature:

Azetidinon III, Et3N, CH2Cl2;

DOI:10.1016/S0040-4039(00)99738-7

Reference yield:

→ 2-[2-Acetylsulfanyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-2-enoic acid 2,2,2-trichloro-ethyl ester (30825-22-0)

Guidance literature:

7g, P(OCH3)3, Ac2O;

upstream raw materials:

6β-(2-phenoxy-acetylamino)-penicillanic acid 2,2,2-trichloro-ethyl ester

acetyl chloride