(S)-2-{(S)-[2-benzyloxycarbonylamino-4-(toluene-4-sulfonylamino)-butyryl]-amino}-4-(toluene-4-sulfonylamino)-butyric acid hydrazide

Base Information

• Chemical Name: (S)-2-{(S)-[2-benzyloxycarbonylamino-4-(toluene-4-sulfonylamino)-butyryl]-amino}-4-(toluene-4-sulfonylamino)-butyric acid hydrazide
• CAS No.: 10270-54-9
• Molecular Formula: C₃₀H₃₈N₆O₈S₂
• Molecular Weight: 674.799
• Mol file: 10270-54-9.mol

Synonyms:

Chemical Property of (S)-2-{(S)-[2-benzyloxycarbonylamino-4-(toluene-4-sulfonylamino)-butyryl]-amino}-4-(toluene-4-sulfonylamino)-butyric acid hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-{(S)-[2-benzyloxycarbonylamino-4-(toluene-4-sulfonylamino)-butyryl]-amino}-4-(toluene-4-sulfonylamino)-butyric acid hydrazide

There total 6 articles about (S)-2-{(S)-[2-benzyloxycarbonylamino-4-(toluene-4-sulfonylamino)-butyryl]-amino}-4-(toluene-4-sulfonylamino)-butyric acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-benzyloxycarbonylamino-4-(toluene-4-sulfonylamino)-butyric acid-[(S)-2-oxo-1-(toluene-4-sulfonyl)-pyrrolidin-3-ylamide] (116107-04-1) → (S)-2-{(S)-[2-benzyloxycarbonylamino-4-(toluene-4-sulfonylamino)-butyryl]-amino}-4-(toluene-4-sulfonylamino)-butyric acid hydrazide (10270-54-9)

Guidance literature:

With 1,4-dioxane; methanol; water; hydrazine;

Reference yield:

(S)-2,4-bis-(toluene-4-sulfonylamino)-butyric acid (25139-85-9) → (S)-2-{(S)-[2-benzyloxycarbonylamino-4-(toluene-4-sulfonylamino)-butyryl]-amino}-4-(toluene-4-sulfonylamino)-butyric acid hydrazide (10270-54-9)

Guidance literature:

Multi-step reaction with 3 steps

1: aqueous HBr; acetic acid; phenol

2: tetraethyl diphosphate(III); diethylphosphonate

3: dioxane; methanol; H₂O; N₂H₄

With 1,4-dioxane; methanol; diphosphorous acid tetraethyl ester; water; hydrogen bromide; acetic acid; phosphonic acid diethyl ester; hydrazine; phenol;

Reference yield:

N2-p-toluenesulfonyl-L-2,4-diaminobutyric acid (62234-29-1) → (S)-2-{(S)-[2-benzyloxycarbonylamino-4-(toluene-4-sulfonylamino)-butyryl]-amino}-4-(toluene-4-sulfonylamino)-butyric acid hydrazide (10270-54-9)

Guidance literature:

Multi-step reaction with 4 steps

1: TsCl

2: aqueous HBr; acetic acid; phenol

3: tetraethyl diphosphate(III); diethylphosphonate

4: dioxane; methanol; H₂O; N₂H₄

With 1,4-dioxane; methanol; diphosphorous acid tetraethyl ester; water; hydrogen bromide; acetic acid; phosphonic acid diethyl ester; p-toluenesulfonyl chloride; hydrazine; phenol;

upstream raw materials:

(S)-2-benzyloxycarbonylamino-4-(toluene-4-sulfonylamino)-butyric acid-[(S)-2-oxo-1-(toluene-4-sulfonyl)-pyrrolidin-3-ylamide]

(S)-2,4-bis-(toluene-4-sulfonylamino)-butyric acid

N2-p-toluenesulfonyl-L-2,4-diaminobutyric acid

(S)-3-amino-1-(toluene-4-sulfonyl)-pyrrolidin-2-one