n-Methylhydrazinecarboxamide

Base Information

• Chemical Name: n-Methylhydrazinecarboxamide
• CAS No.: 17696-95-6
• Molecular Formula: C2H7 N3 O
• Molecular Weight: 89.0971
• European Community (EC) Number: 803-212-9
• NSC Number: 82194
• DSSTox Substance ID: DTXSID60292383
• Nikkaji Number: J1.604.966B
• Wikidata: Q82030672
• Mol file: 17696-95-6.mol

Synonyms:n-methylhydrazinecarboxamide;1-amino-3-methylurea;17696-95-6;4-methylsemicarbazide;MFCD02676511;NSC82194;Hydrazinecarboxamide, N-methyl-;3-amino-1-methylurea;Semicarbazide, 4-methyl-;N-methylhydrazine-carboxamide;DTXSID60292383;1-Amino-3-methylurea, AldrichCPR;AMY42564;BCP16651;NSC 82194;NSC-82194;AKOS009344134;SB86394;CS-0210256;FT-0697840;EN300-54176;A50867;A881485;HydrazinecarboxaMide, N-Methyl-;N-MethylhydrazinecarboxaMide;1-AMino-3-Methylurea

Chemical Property of n-Methylhydrazinecarboxamide

Chemical Property:

• Melting Point: 112 °C
• PKA: 12.29±0.20(Predicted)
• PSA: 67.15000
• Density: 1.114g/cm³
• LogP: 0.27120
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: -2.2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 89.058911855
• Heavy Atom Count: 6
• Complexity: 52.8

Purity/Quality:

99% ^*data from raw suppliers

N-Methylhydrazinecarboxamide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC(=O)NN
• Uses: N-Methylhydrazinecarboxamide is used in preparation of heteroarylalkylene aryl sultam derivatives as RORc modulators.

Technology Process of n-Methylhydrazinecarboxamide

There total 11 articles about n-Methylhydrazinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Methyl-O-phenylcarbamat (1943-79-9) → 4-methylsemicarbazide (17696-95-6)

Guidance literature:

With hydrazine hydrate; In isopropyl alcohol; at 75 ℃; for 6h;

DOI:10.1021/ol503625z

Reference yield:

1,3 dimethyl 1 nitrosourea (13256-32-1) → 4-methylsemicarbazide (17696-95-6)

Guidance literature:

With water; hydrazine;

DOI:10.1139/v51-056

Reference yield:

methyl isocyanate (624-83-9) → 4-methylsemicarbazide (17696-95-6)

Guidance literature:

With diethyl ether; hydrazine;

upstream raw materials:

1,3 dimethyl 1 nitrosourea

methyl isocyanate

pyrocatechol monomethylcarbamate

4-methylthiosemicarbazide

Downstream raw materials:

1-(2-Chloroethyl)-6-methylbiurea

5-Amino-N-methyl-3-phenyl-1H-pyrazol-1-carboxamid

C₁₉H₂₀N₄O₆

4-fluoro-N-[(methylcarbamoyl)amino]benzamide

Refernces

• 1、 -. "1,2,4-TRIAZOLINOE CB1 INHIBITORS". Page/Page column 45. . Retrieved 2021/09/11.
• 2、 -. "PROCESS FOR MAKING REVERSE TRANSCRIPTASE INHIBITORS". Page/Page column 13. . Retrieved 2015/06/18.