1943-79-9Relevant articles and documents
A very concise synthesis of a potent N-(1,3-thiazol-2-yl)pyridin-2-amine KDR kinase inhibitor
Zhao, Matthew,Yin, Jingjun,Huffman, Mark A.,McNamara, James M.
, p. 1110 - 1115 (2006)
A very concise synthesis of a potent KDR kinase inhibitor 1 is described. The synthesis features an exceedingly efficient one-pot preparation of the aminothiazole 6 followed by Pd-Xantphos catalyzed cross-coupling with chloropyridine aldehyde 11. Reductiv
The synthesis of phenyl carbamates catalyzed by iron (II) bromide: An oxidative approach for cross-coupling of phenols with formamides
Adurthi, Suryakumari,Sudhakar, Chithaluri,Vala, Manoj Kumar,Vanam, Shekhar
, (2021/12/30)
The carbamate group is a key structural motif in many approved drugs and pro-drugs. There is increasing use of carbamates in the medicinal chemistry and agrochemical industry. We present, reagents and chemical methodologies for the synthesis of carbamates, and recent applications. The direct coupling of simple phenols with mono- and di-alkyl formamides provided the phenylcarbamate products.
Highly efficient synthesis of hiv nnrti doravirine
Gauthier, Donald R.,Sherry, Benjamin D.,Cao, Yang,Journet, Michel,Humphrey, Guy,Itoh, Tetsuji,Mangion, Ian,Tschaen, David M.
supporting information, p. 1353 - 1356 (2015/03/30)
The development of an efficient and robust process for the production of HIV NNRTI doravirine is described. The synthesis features a continuous aldol reaction as part of a de novo synthesis of the key pyridone fragment. Conditions for the continuous flow aldol reaction were derived using microbatch snapshots of the flow process.
