(2S^*,4aS^*,5S^*,8aR^*)-1-benzyl-2-(1-propyl)-(Δ-3,4)-5-methyl-(Δ-6,7)-7-<(trifluoromethanesulfonyl)oxy>hexahydroquinoline

Base Information

• Chemical Name: (2S^*,4aS^*,5S^*,8aR^*)-1-benzyl-2-(1-propyl)-(Δ-3,4)-5-methyl-(Δ-6,7)-7-<(trifluoromethanesulfonyl)oxy>hexahydroquinoline
• CAS No.: 142003-59-6
• Molecular Formula: C₂₁H₂₆F₃NO₃S
• Molecular Weight: 429.504
• Mol file: 142003-59-6.mol

Synonyms:

Chemical Property of (2S^*,4aS^*,5S^*,8aR^*)-1-benzyl-2-(1-propyl)-(Δ-3,4)-5-methyl-(Δ-6,7)-7-<(trifluoromethanesulfonyl)oxy>hexahydroquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S^*,4aS^*,5S^*,8aR^*)-1-benzyl-2-(1-propyl)-(Δ-3,4)-5-methyl-(Δ-6,7)-7-<(trifluoromethanesulfonyl)oxy>hexahydroquinoline

There total 1 articles about (2S^*,4aS^*,5S^*,8aR^*)-1-benzyl-2-(1-propyl)-(Δ-3,4)-5-methyl-(Δ-6,7)-7-<(trifluoromethanesulfonyl)oxy>hexahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-phenylbistrifluoromethane-sulfonimide (37595-74-7) + lithium dimethylcuprate (15681-48-8) + (2S,4aS,8aR)-1-Benzyl-2-propyl-2,4a,8,8a-tetrahydro-1H-quinolin-7-one (142003-72-3) → (2S*,4aS*,5S*,8aR*)-1-benzyl-2-(1-propyl)-(Δ-3,4)-5-methyl-(Δ-6,7)-7-<(trifluoromethanesulfonyl)oxy>hexahydroquinoline (142003-59-6)

Guidance literature:

Yield given. Multistep reaction; 1) THF, a) -78 deg C, 45 min, b) 0 deg C, 35 min, 2) THF, a) 0 deg C, 2 h, b) r.t., 1 h;

DOI:10.1021/jo00041a012

Reference yield: 60.0%

(2S*,4aS*,5S*,8aR*)-1-benzyl-2-(1-propyl)-(Δ-3,4)-5-methyl-(Δ-6,7)-7-<(trifluoromethanesulfonyl)oxy>hexahydroquinoline (142003-59-6) → (+/-)-pumiliotoxine C hydrochloride (55785-30-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 20h; under 760 Torr;

DOI:10.1021/jo00041a012

upstream raw materials:

N,N-phenylbistrifluoromethane-sulfonimide

lithium dimethylcuprate

(2S,4aS,8aR)-1-Benzyl-2-propyl-2,4a,8,8a-tetrahydro-1H-quinolin-7-one

Downstream raw materials:

(+/-)-pumiliotoxine C hydrochloride