2-(3-acetylamino-4-methyl-phenyl)-3-phenyl-propionitrile

Base Information

• Chemical Name: 2-(3-acetylamino-4-methyl-phenyl)-3-phenyl-propionitrile
• CAS No.: 101792-59-0
• Molecular Formula: C₁₈H₁₈N₂O
• Molecular Weight: 278.354
• Mol file: 101792-59-0.mol

Synonyms:

Chemical Property of 2-(3-acetylamino-4-methyl-phenyl)-3-phenyl-propionitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-acetylamino-4-methyl-phenyl)-3-phenyl-propionitrile

There total 10 articles about 2-(3-acetylamino-4-methyl-phenyl)-3-phenyl-propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-(3-acetylamino-4-methyl-phenyl)-3-phenyl-propionitrile (101792-59-0)

Guidance literature:

With palladium on activated charcoal; ethanol; Hydrogenation_.Erhitzen des Reaktionsprodukts mit Acetanhydrid;

DOI:10.1007/BF00900970

Reference yield:

2-(3-amino-4-methyl-phenyl)-3c-phenyl-acrylonitrile (131408-96-3) → 2-(3-acetylamino-4-methyl-phenyl)-3-phenyl-propionitrile (101792-59-0)

Guidance literature:

With palladium on activated charcoal; ethanol; Hydrogenation_.Erhitzen des Reaktionsprodukts mit Acetanhydrid;

DOI:10.1007/BF00900970

Reference yield:

(Z)-3-phenyl-2-(p-tolyl)acrylonitrile (25125-30-8) → 2-(3-acetylamino-4-methyl-phenyl)-3-phenyl-propionitrile (101792-59-0)

Guidance literature:

Multi-step reaction with 6 steps

1: bromine / Irradiation

2: diethyl ether; AgN₃ / -10 °C

3: palladium/charcoal; acetic acid anhydride; acetic acid / Hydrogenation

4: aqueous methanol. KOH

5: aq.-ethanolic HCl

6: palladium/charcoal; ethanol / Hydrogenation_.Erhitzen des Reaktionsprodukts mit Acetanhydrid in Benzol

With hydrogenchloride; potassium hydroxide; palladium on activated charcoal; silver(I) azide; diethyl ether; ethanol; bromine; acetic anhydride; acetic acid;

DOI:10.1007/BF00900970

upstream raw materials:

2-(3-amino-4-methyl-phenyl)-3c-phenyl-acrylonitrile

(Z)-3-phenyl-2-(p-tolyl)acrylonitrile

4-bromomethyl-1-methyl-2-nitro-benzene

2-(3-acetylamino-4-methyl-phenyl)-3c-phenyl-acrylonitrile