25125-30-8

Basic information

• Product Name: Benzeneacetonitrile, 4-methyl-a-(phenylmethylene)-, (Z)-
• CAS NO: 25125-30-8
• Molecular Formula: C16H13N
• Molecular Weight: 219.286
• Mol File: 25125-30-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzeneacetonitrile, 4-methyl-a-(phenylmethylene)-, (Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetonitrile, 4-methyl-a-(phenylmethylene)-, (Z)-(25125-30-8)
• EPA Substance Registry System: Benzeneacetonitrile, 4-methyl-a-(phenylmethylene)-, (Z)-(25125-30-8)

Safety Data

• Hazardous Substances Data: 25125-30-8(Hazardous Substances Data)

Upstream product

• 2947-61-7 (4-methylphenyl)acetonitrile 
• 4086-15-1 3-phenyl-1-(1H-pyrrol-2-yl)-2-propen-1-one 
• 100-53-8 phenylmethanethiol 
• 104-81-4 4-Methylbenzyl bromide 
• 589-18-4 4-Methylbenzyl alcohol 
• 99-75-2 4-methyl-benzoic acid methyl ester 
• 100-52-7 benzaldehyde 
• 104-87-0 4-methyl-benzaldehyde 
• 95549-09-0 (4-Dimethylamino-phenylsulfanyl)-p-tolyl-acetonitrile 

Downstream Products

• 132105-54-5 2,3-dibromo-3-phenyl-2-p-tolyl-propionitrile 
• 101118-43-8 3-azido-2-(4-azido-4-methyl-cyclohexa-2,5-dienylidene)-3-phenyl-propionitrile 
• 101792-59-0 2-(3-acetylamino-4-methyl-phenyl)-3-phenyl-propionitrile 
• 117122-24-4 2-(3-diacetylamino-4-methyl-phenyl)-3c-phenyl-acrylonitrile 
• 131620-24-1 2-(3-acetylamino-4-methyl-phenyl)-3c-phenyl-acrylonitrile 
• 131408-96-3 2-(3-amino-4-methyl-phenyl)-3c-phenyl-acrylonitrile 

Relevant articles and documents

Pd(II)-Catalyzed CC Bond Cleavage by a Formal Group-Exchange Reaction

A chelation-assisted palladium-catalyzed CC bond cleavage of α, β-unsaturated ketone to form alkenyl nitrile in the presence of nitrile is disclosed on the basis of a formal group-exchange reaction formulated as C1C2 + C3 → C1C3 + C2, differing from normal alkene oxidative cleavage and metathesis type. The isolated key active Pd(II) complex as well as deuterium-labeled experiment revealed the necessity of the chelation group, and a plausible catalytic pathway was proposed.

Combretastatin A4 analogue containing cyanoethylene joining chain and application in preparing antitumor drugs

The invention a Combretastatin A4 analogue containing a cyanoethylene joining chain and an application in preparing antitumor drugs, which relates to the field of a medicinal compound. A structural formula (I-IV) is shown as the specification, an anticancer candidate compound which has strong inhibitory activity against cancer cells and is not toxic to normal cells is currently lacked, for the reason, the method prepares 19 I-IV series compounds, and the para and meta positions of the B ring (benzene ring) introduce various alkyl groups, alkoxy groups or amino substituents or replace the B ring (benzene ring) with various heterocyclic rings. In the I-series compound, when the para position of the B ring (benzene ring) is substituted with an ethyl group, an isopropyl group, a dimethylaminogroup or a diethylamino group, the proliferation resistance of the cancer cells is very strong, and toxicity is weak for the L-02 normal cells, a selective anticancer activity coefficient (an IC50 value ratio of L-02 normal cells to cancer cells) can even exceed 10,000, and the four compounds have the potential to be developed into safe and highly effective anticancer drugs.

Kinetic Study of the Base-catalysed Reactions of Benzaldahehyde and Thiophene-2-carbaldehyde with Acetonitriles

The reaction rates of the sodium methoxide-catalysed condensation of benzaldehyde and thiophene-2-carbaldehyde with heteroaromatic acetonitriles ArCH2CN; Ar = C6H5, C6H4CH3(p), C6H4-OCH3(p), C6H4F(p), C6H4Cl(p), C6H4Br(p), 2-thienyl, 3-thienyl, 3-pyridyl