1-Pyrrolidinecarboxylic acid, 2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-3-(2-hydroxyethyl)-4-[(tri methylsilyl)methylene]-, phenyl ester

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-3-(2-hydroxyethyl)-4-[(tri methylsilyl)methylene]-, phenyl ester
CAS No.:141277-34-1
Molecular Formula:C24H41NO4Si2
Molecular Weight:463.765
Hs Code.:

1-Pyrrolidinecarboxylic acid,
2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-3-(2-hydroxyethyl)-4-[(tri
methylsilyl)methylene]-, phenyl ester

Synonyms:

Suppliers and Price of 1-Pyrrolidinecarboxylic acid, 2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-3-(2-hydroxyethyl)-4-[(tri methylsilyl)methylene]-, phenyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-3-(2-hydroxyethyl)-4-[(tri methylsilyl)methylene]-, phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-Pyrrolidinecarboxylic acid, 2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-3-(2-hydroxyethyl)-4-[(tri methylsilyl)methylene]-, phenyl ester

There total 8 articles about 1-Pyrrolidinecarboxylic acid, 2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-3-(2-hydroxyethyl)-4-[(tri methylsilyl)methylene]-, phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 141277-33-0
[(E)-(R)-1-(tert-Butyl-dimethyl-silanyloxymethyl)-4-oxo-but-2-enyl]-(3-trimethylsilanyl-prop-2-ynyl)-carbamic acid phenyl ester

: 141277-34-1
(4R)-N-(phenyloxycarbonyl)-2-<(tert-butyldimethylsilyl)oxymethyl>-3-(2-hydroxyethyl)-4-(trimethylsilylmethylenyl)pyrrolidine

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; samarium diiodide; tert-butyl alcohol; In tetrahydrofuran; at 0 ℃; for 0.116667h;
DOI:10.1016/S0040-4039(00)91663-0

Reference yield: 10.0%

: 141277-33-0
(4S)-4-<(phenyloxycarbonyl)(3-trimethylsilylprop-2-ynyl)amino>-5-<(tert-butyldimethylsilyl)oxy>pent-2-en-1-al

: 141277-34-1
(4R)-N-(phenyloxycarbonyl)-2-<(tert-butyldimethylsilyl)oxymethyl>-3-(2-hydroxyethyl)-4-(trimethylsilylmethylenyl)pyrrolidine

: (4R)-N-(phenyloxycarbonyl)-2-<(tert-butyldimethylsilyl)oxymethyl>-3-(ethan-2-al)-4-(trimethylsilylmethylenyl)pyrrolidine

Guidance literature:: With samarium diiodide; tert-butyl alcohol; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at 0 ℃; for 0.25h;
DOI:10.1016/S0040-4020(01)85517-4

Reference yield:

: 5272-36-6
3-trimethylsilyl-2-propyn-1-ol

: 141277-34-1
(4R)-N-(phenyloxycarbonyl)-2-<(tert-butyldimethylsilyl)oxymethyl>-3-(2-hydroxyethyl)-4-(trimethylsilylmethylenyl)pyrrolidine

Guidance literature:: Multi-step reaction with 6 steps

1: 43 percent / triphenylphosphine, bromine / dimethylformamide / 18 h / Ambient temperature

2: 20 percent / Et₃N / toluene / 70 deg C, 2 h, then --> room temp., 3 h

3: 96 percent / sat. sodium bicarbonate / ethyl acetate; H₂O / 2 h / 0 °C

4: diisobutylaluminium hydride / toluene / 5 h / -78 °C

5: 32 percent / CH₂Cl₂ / 18 h / Ambient temperature

6: 25 percent / samarium(II) iodide, tert-butanol / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.25 h / 0 °C

With samarium diiodide; bromine; diisobutylaluminium hydride; sodium hydrogencarbonate; triethylamine; triphenylphosphine; tert-butyl alcohol; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(01)85517-4