(S)-2-benzyloxycarbonylamino-4-(toluene-4-sulfonylamino)-butyryl=>(S)-2-amino-4-(toluene-4-sulfonylamino)-butyryl=>L-serine methyl ester

Base Information

• Chemical Name: (S)-2-benzyloxycarbonylamino-4-(toluene-4-sulfonylamino)-butyryl=>(S)-2-amino-4-(toluene-4-sulfonylamino)-butyryl=>L-serine methyl ester
• CAS No.: 120969-53-1
• Molecular Formula: C₃₄H₄₃N₅O₁₁S₂
• Molecular Weight: 761.874
• Mol file: 120969-53-1.mol

Synonyms:

Chemical Property of (S)-2-benzyloxycarbonylamino-4-(toluene-4-sulfonylamino)-butyryl=>(S)-2-amino-4-(toluene-4-sulfonylamino)-butyryl=>L-serine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-benzyloxycarbonylamino-4-(toluene-4-sulfonylamino)-butyryl=>(S)-2-amino-4-(toluene-4-sulfonylamino)-butyryl=>L-serine methyl ester

There total 5 articles about (S)-2-benzyloxycarbonylamino-4-(toluene-4-sulfonylamino)-butyryl=>(S)-2-amino-4-(toluene-4-sulfonylamino)-butyryl=>L-serine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2,4-bis-(toluene-4-sulfonylamino)-butyric acid (25139-85-9) → (S)-2-benzyloxycarbonylamino-4-(toluene-4-sulfonylamino)-butyryl=>(S)-2-amino-4-(toluene-4-sulfonylamino)-butyryl=>L-serine methyl ester (120969-53-1)

Guidance literature:

Multi-step reaction with 3 steps

1: aqueous HBr; acetic acid; phenol

2: tetraethyl diphosphate(III); diethylphosphonate

3: nitromethane

With nitromethane; diphosphorous acid tetraethyl ester; hydrogen bromide; acetic acid; phosphonic acid diethyl ester; phenol;

Reference yield:

N2-p-toluenesulfonyl-L-2,4-diaminobutyric acid (62234-29-1) → (S)-2-benzyloxycarbonylamino-4-(toluene-4-sulfonylamino)-butyryl=>(S)-2-amino-4-(toluene-4-sulfonylamino)-butyryl=>L-serine methyl ester (120969-53-1)

Guidance literature:

Multi-step reaction with 4 steps

1: TsCl

2: aqueous HBr; acetic acid; phenol

3: tetraethyl diphosphate(III); diethylphosphonate

4: nitromethane

With nitromethane; diphosphorous acid tetraethyl ester; hydrogen bromide; acetic acid; phosphonic acid diethyl ester; p-toluenesulfonyl chloride; phenol;

Reference yield:

(S)-2-amino-4-(toluene-4-sulfonylamino)-butyric acid (5364-59-0) → (S)-2-benzyloxycarbonylamino-4-(toluene-4-sulfonylamino)-butyryl=>(S)-2-amino-4-(toluene-4-sulfonylamino)-butyryl=>L-serine methyl ester (120969-53-1)

Guidance literature:

Multi-step reaction with 3 steps

1: dioxane

2: tetraethyl diphosphate(III); diethylphosphonate

3: nitromethane

With 1,4-dioxane; nitromethane; diphosphorous acid tetraethyl ester; phosphonic acid diethyl ester;

upstream raw materials:

(S)-2,4-bis-(toluene-4-sulfonylamino)-butyric acid

N2-p-toluenesulfonyl-L-2,4-diaminobutyric acid

(S)-3-amino-1-(toluene-4-sulfonyl)-pyrrolidin-2-one

(S)-2-amino-4-(toluene-4-sulfonylamino)-butyric acid