1H-Indole, 3-(4-fluorophenyl)-2,5-dimethyl-1-(4-pyridinyl)-

Base Information

Chemical Name:1H-Indole, 3-(4-fluorophenyl)-2,5-dimethyl-1-(4-pyridinyl)-
CAS No.:141306-67-4
Molecular Formula:C21H17FN2
Molecular Weight:316.37100
Hs Code.:
Mol file:141306-67-4.mol

Synonyms:3-(4-Fluoro-phenyl)-2,5-dimethyl-1-pyridin-4-yl-1H-indole;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Indole, 3-(4-fluorophenyl)-2,5-dimethyl-1-(4-pyridinyl)-

Chemical Property:

PSA：17.82000
LogP:5.44840

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 1H-Indole, 3-(4-fluorophenyl)-2,5-dimethyl-1-(4-pyridinyl)-

There total 1 articles about 1H-Indole, 3-(4-fluorophenyl)-2,5-dimethyl-1-(4-pyridinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 19524-06-2
4-bromopyridine hydrochloride

: 141306-71-0
2,5-dimethyl-3-(4-fluorophenyl)-1H-indole

: 141306-67-4
2,5-dimethyl-3-(4-fluorophenyl)-1-(4-pyridinyl)-1H-indole

Guidance literature:: With potassium carbonate; copper(I) bromide; In various solvent(s); for 18h; Heating;
DOI:10.1021/jm00104a007

Reference yield:

: 141306-67-4
2,5-dimethyl-3-(4-fluorophenyl)-1-(4-pyridinyl)-1H-indole

: 2,5-dimethyl-3-(4-fluorophenyl)-1-(1-methyl-4-piperidinyl)-1H-indole

Guidance literature:: Multi-step reaction with 3 steps

1: acetone / 40 °C

2: NaBH₄ / ethanol / 3.5 h

3: ammonium formate / 5percent Pd/C / ethanol / 25 h / Heating

With sodium tetrahydroborate; ammonium formate; palladium on activated charcoal; In ethanol; acetone;
DOI:10.1021/jm00104a007

Reference yield:

: 141306-67-4
2,5-dimethyl-3-(4-fluorophenyl)-1-(4-pyridinyl)-1H-indole

: 141307-07-5
Lu 29066

Guidance literature:: Multi-step reaction with 3 steps

1: various solvent(s) / 6 h / Heating

2: NaBH₄ / ethanol / 3.5 h

3: 38 percent / ammonium formate / 5percent Pd/C / ethanol / 25 h / Heating

With sodium tetrahydroborate; ammonium formate; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00104a007