2-Propenoic acid, 3-[6-[[(3-aminophenyl)sulfonyl]methyl]-3-[[8-(4-methoxyphenyl)octyl]oxy]- 2-pyridinyl]-, methyl ester, (E)-

Base Information

Chemical Name:2-Propenoic acid, 3-[6-[[(3-aminophenyl)sulfonyl]methyl]-3-[[8-(4-methoxyphenyl)octyl]oxy]- 2-pyridinyl]-, methyl ester, (E)-
CAS No.:141311-12-8
Molecular Formula:C31H38N2O6S
Molecular Weight:566.719
Hs Code.:
Mol file:141311-12-8.mol

Synonyms:

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Chemical Property of 2-Propenoic acid, 3-[6-[[(3-aminophenyl)sulfonyl]methyl]-3-[[8-(4-methoxyphenyl)octyl]oxy]- 2-pyridinyl]-, methyl ester, (E)-

Chemical Property:

Purity/Quality:

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Technology Process of 2-Propenoic acid, 3-[6-[[(3-aminophenyl)sulfonyl]methyl]-3-[[8-(4-methoxyphenyl)octyl]oxy]- 2-pyridinyl]-, methyl ester, (E)-

There total 15 articles about 2-Propenoic acid, 3-[6-[[(3-aminophenyl)sulfonyl]methyl]-3-[[8-(4-methoxyphenyl)octyl]oxy]- 2-pyridinyl]-, methyl ester, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 141311-08-2
(E)-3-{6-(3-Amino-phenylsulfanylmethyl)-3-[8-(4-methoxy-phenyl)-octyloxy]-pyridin-2-yl}-acrylic acid methyl ester

: 141311-12-8
(E)-3-{6-(3-Amino-benzenesulfonylmethyl)-3-[8-(4-methoxy-phenyl)-octyloxy]-pyridin-2-yl}-acrylic acid methyl ester

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 1.5h;
DOI:10.1021/jm00074a013

Reference yield:

: 14916-80-4
oct-3-yn-1-ol

: 141311-12-8
(E)-3-{6-(3-Amino-benzenesulfonylmethyl)-3-[8-(4-methoxy-phenyl)-octyloxy]-pyridin-2-yl}-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 13 steps

1: 97 percent / potassium hydride, 1,3-diaminopropane / 18 h / Ambient temperature

2: 93 percent / imidazole / dimethylformamide / 2 h / Ambient temperature

3: 93 percent / (Ph₃P)2PdCl₂, Et₃N, CuI / 4 h / 50 °C

4: H₂ / 5percent Pd/C / ethanol; ethyl acetate / 4 h

5: tetrabutylammonium fluoride / tetrahydrofuran / 4.5 h / Ambient temperature

6: 90 percent / triphenylphosphine, imidazole, I₂ / toluene / 0.5 h / 65 °C

7: K₂CO₃ / dimethylformamide / 1 h / 90 °C

8: toluene / 1 h / 50 °C

9: 85percent MCPBA / CH₂Cl₂ / 1.) 0 deg C, 30 min, 2.) RT, 16 h

10: trifluoroacetic anhydride / dimethylformamide / 16 h / Ambient temperature

11: thionyl chloride / toluene / 1.5 h / 0 - 20 °C

12: K₂CO₃ / dimethylformamide / 1 h / 90 °C

13: MCPBA / CH₂Cl₂ / 1.5 h / 0 °C

With 1H-imidazole; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; thionyl chloride; tetrabutyl ammonium fluoride; hydrogen; iodine; potassium hydride; potassium carbonate; Trimethylenediamine; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; trifluoroacetic anhydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00074a013

Reference yield:

: 871-91-0
oct-7-yn-1-ol

: 141311-12-8
(E)-3-{6-(3-Amino-benzenesulfonylmethyl)-3-[8-(4-methoxy-phenyl)-octyloxy]-pyridin-2-yl}-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: 93 percent / imidazole / dimethylformamide / 2 h / Ambient temperature

2: 93 percent / (Ph₃P)2PdCl₂, Et₃N, CuI / 4 h / 50 °C

3: H₂ / 5percent Pd/C / ethanol; ethyl acetate / 4 h

4: tetrabutylammonium fluoride / tetrahydrofuran / 4.5 h / Ambient temperature

5: 90 percent / triphenylphosphine, imidazole, I₂ / toluene / 0.5 h / 65 °C

6: K₂CO₃ / dimethylformamide / 1 h / 90 °C

7: toluene / 1 h / 50 °C

8: 85percent MCPBA / CH₂Cl₂ / 1.) 0 deg C, 30 min, 2.) RT, 16 h

9: trifluoroacetic anhydride / dimethylformamide / 16 h / Ambient temperature

10: thionyl chloride / toluene / 1.5 h / 0 - 20 °C

11: K₂CO₃ / dimethylformamide / 1 h / 90 °C

12: MCPBA / CH₂Cl₂ / 1.5 h / 0 °C

With 1H-imidazole; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; thionyl chloride; tetrabutyl ammonium fluoride; hydrogen; iodine; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; trifluoroacetic anhydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00074a013