Technology Process of 2-Propenoic acid,
3-[3-[[8-(4-methoxyphenyl)octyl]oxy]-6-methyl-1-oxido-2-pyridinyl]-,
methyl ester, (E)-
There total 11 articles about 2-Propenoic acid,
3-[3-[[8-(4-methoxyphenyl)octyl]oxy]-6-methyl-1-oxido-2-pyridinyl]-,
methyl ester, (E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
DOI:10.1021/jm00070a015
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 97 percent / potassium hydride, 1,3-diaminopropane / 18 h / Ambient temperature
2: 93 percent / imidazole, / dimethylformamide / 2 h / Ambient temperature
3: 93 percent / Et3N, CuI / (Ph3P)2PdCl2 / 4 h / 50 °C
4: 93 percent / H2 / 5percent Pd-C / ethanol; ethyl acetate / 4 h
5: 1 M tetrabutylammonium fluoride / tetrahydrofuran / 4.5 h / Ambient temperature
6: 90 percent / triphenylphosphine, imidazole, I2 / toluene / 0.5 h / 65 °C
7: K2CO3 / dimethylformamide / 1.5 h / 90 °C
8: toluene / 1 h / 50 °C
9: 50percent m-chloroperoxybenzoic acid / CH2Cl2 / 15 h / Ambient temperature
With
1H-imidazole; copper(l) iodide; tetrabutyl ammonium fluoride; hydrogen; iodine; potassium hydride; potassium carbonate; Trimethylenediamine; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine;
bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00046a017
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 93 percent / imidazole, / dimethylformamide / 2 h / Ambient temperature
2: 93 percent / Et3N, CuI / (Ph3P)2PdCl2 / 4 h / 50 °C
3: 93 percent / H2 / 5percent Pd-C / ethanol; ethyl acetate / 4 h
4: 1 M tetrabutylammonium fluoride / tetrahydrofuran / 4.5 h / Ambient temperature
5: 90 percent / triphenylphosphine, imidazole, I2 / toluene / 0.5 h / 65 °C
6: K2CO3 / dimethylformamide / 1.5 h / 90 °C
7: toluene / 1 h / 50 °C
8: 50percent m-chloroperoxybenzoic acid / CH2Cl2 / 15 h / Ambient temperature
With
1H-imidazole; copper(l) iodide; tetrabutyl ammonium fluoride; hydrogen; iodine; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine;
bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00046a017
