4H-Pyrimido(6,1-a)isoquinolin-4-one, 2,3,6,7-tetrahydro-9,10-dimethoxy-3,7-dimethyl-2-((4-fluorophenyl)imino)-, monohydrochloride, (+-)-

Base Information

Chemical Name:4H-Pyrimido(6,1-a)isoquinolin-4-one, 2,3,6,7-tetrahydro-9,10-dimethoxy-3,7-dimethyl-2-((4-fluorophenyl)imino)-, monohydrochloride, (+-)-
CAS No.:108445-81-4
Molecular Formula:C₂₂H₂₂FN₃O₃*ClH
Molecular Weight:431.894
Hs Code.:

Synonyms:108445-81-4;4H-Pyrimido(6,1-a)isoquinolin-4-one, 2,3,6,7-tetrahydro-9,10-dimethoxy-3,7-dimethyl-2-((4-fluorophenyl)imino)-, monohydrochloride, (+-)-;LS-136211

Suppliers and Price of 4H-Pyrimido(6,1-a)isoquinolin-4-one, 2,3,6,7-tetrahydro-9,10-dimethoxy-3,7-dimethyl-2-((4-fluorophenyl)imino)-, monohydrochloride, (+-)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4H-Pyrimido(6,1-a)isoquinolin-4-one, 2,3,6,7-tetrahydro-9,10-dimethoxy-3,7-dimethyl-2-((4-fluorophenyl)imino)-, monohydrochloride, (+-)-

Chemical Property:

Vapor Pressure:2.75E-12mmHg at 25°C
Boiling Point:553.3°Cat760mmHg
Flash Point:288.4°C
Density:g/cm³
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:431.1411975
Heavy Atom Count:30
Complexity:689

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CN2C(=CC(=NC3=CC=C(C=C3)F)N(C2=O)C)C4=CC(=C(C=C14)OC)OC.Cl

Technology Process of 4H-Pyrimido(6,1-a)isoquinolin-4-one, 2,3,6,7-tetrahydro-9,10-dimethoxy-3,7-dimethyl-2-((4-fluorophenyl)imino)-, monohydrochloride, (+-)-

There total 5 articles about 4H-Pyrimido(6,1-a)isoquinolin-4-one, 2,3,6,7-tetrahydro-9,10-dimethoxy-3,7-dimethyl-2-((4-fluorophenyl)imino)-, monohydrochloride, (+-)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 66432-29-9
(+/-)-2-(3,4-dimethoxyphenyl)propylamine hydrochloride

: 108445-81-4
2-[(E)-4-Fluoro-phenylimino]-9,10-dimethoxy-3,7-dimethyl-2,3,6,7-tetrahydro-pyrimido[6,1-a]isoquinolin-4-one; hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: H₂O / 2 h / 50 °C / 2 h addition at 50 deg C

2: 90 percent / Na / ethanol / 20 h / Heating

3: 95 percent / POCl₃ / 24 h / 80 °C

4: CHCl₃ / 20 h / Heating

5: K₂CO₃ / acetone / 3 h / Heating

With sodium; potassium carbonate; trichlorophosphate; In ethanol; chloroform; water; acetone;
DOI:10.1002/hlca.19860690722

Reference yield:

: 94564-47-3
N-<2-(3,4-Dimethoxyphenyl)propyl>harnstoff

: 108445-81-4
2-[(E)-4-Fluoro-phenylimino]-9,10-dimethoxy-3,7-dimethyl-2,3,6,7-tetrahydro-pyrimido[6,1-a]isoquinolin-4-one; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / Na / ethanol / 20 h / Heating

2: 95 percent / POCl₃ / 24 h / 80 °C

3: CHCl₃ / 20 h / Heating

4: K₂CO₃ / acetone / 3 h / Heating

With sodium; potassium carbonate; trichlorophosphate; In ethanol; chloroform; acetone;
DOI:10.1002/hlca.19860690722

Reference yield:

: 94564-48-4
1-<2-(3,4-Dimethoxyphenyl)propyl>pyrimidin-2,4,6(1H,3H,5H)-trion

: 108445-81-4
2-[(E)-4-Fluoro-phenylimino]-9,10-dimethoxy-3,7-dimethyl-2,3,6,7-tetrahydro-pyrimido[6,1-a]isoquinolin-4-one; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / POCl₃ / 24 h / 80 °C

2: CHCl₃ / 20 h / Heating

3: K₂CO₃ / acetone / 3 h / Heating

With potassium carbonate; trichlorophosphate; In chloroform; acetone;
DOI:10.1002/hlca.19860690722