1-{(2R,4R,5R)-5-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-4-phenylselanyl-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

Base Information

• Chemical Name: 1-{(2R,4R,5R)-5-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-4-phenylselanyl-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione
• CAS No.: 130446-05-8
• Molecular Formula: C₃₆H₃₄N₂O₅Se
• Molecular Weight: 653.636
• Mol file: 130446-05-8.mol

Synonyms:

Chemical Property of 1-{(2R,4R,5R)-5-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-4-phenylselanyl-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-{(2R,4R,5R)-5-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-4-phenylselanyl-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

There total 3 articles about 1-{(2R,4R,5R)-5-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-4-phenylselanyl-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

thymin (65-71-4,28806-14-6,691841-57-3) → 1-{(2R,4R,5R)-5-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-4-phenylselanyl-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione (130446-05-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / Ambient temperature

2: 1) pyridine, 2) LiAlH₄ / 1) r.t., 6 h, 2) THF, reflux 4 h

With pyridine; lithium aluminium tetrahydride;

DOI:10.1016/S0040-4020(01)91032-4

Reference yield:

mono-4-methoxytrityl chloride (14470-28-1) → 1-{(2R,4R,5R)-5-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-4-phenylselanyl-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione (130446-05-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / Ambient temperature

2: 1) pyridine, 2) LiAlH₄ / 1) r.t., 6 h, 2) THF, reflux 4 h

With pyridine; lithium aluminium tetrahydride;

DOI:10.1016/S0040-4020(01)91032-4

Reference yield:

diphenyl diselenide (1666-13-3) + (2R,4R,5R)-1-[5-[bis(4-methoxyphenyl)phenylmethoxymethyl]-4-hydroxytetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione (124680-51-9) + methanesulfonyl chloride (124-63-0) → 1-{(2R,4R,5R)-5-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-4-phenylselanyl-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione (130446-05-8)

Guidance literature:

With pyridine; lithium aluminium tetrahydride; Yield given. Multistep reaction; 1) r.t., 6 h, 2) THF, reflux 4 h;

DOI:10.1016/S0040-4020(01)91032-4

upstream raw materials:

diphenyl diselenide

(2R,4R,5R)-1-[5-[bis(4-methoxyphenyl)phenylmethoxymethyl]-4-hydroxytetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

methanesulfonyl chloride

thymin

Downstream raw materials:

1-<2',3'-dideoxy-3'(R)-phenylseleno-β-D-glycero-pentofuranosyl>thymine

1-<5'-O-allyl-2',3'-dideoxy-3'(R)-phenylseleno-β-D-glycero-pentofuranosyl>thymine

1-<5'-O-(1-oxo-prop-2-ene-1yl)-2',3'-dideoxy-3'(R)-phenylseleno-β-D-glycero-pentofuranosyl>thymine

1-<5'-O-(2-propynyl)-2',3'-dideoxy-3'(R)-phenylseleno-β-D-glycero-pentofuranosyl>thymine